Stem cell therapy in intracerebral hemorrhage rat model

Table 1 Methodologies used in preclinical trials of stem cell therapy for intracerebral hemorrhage

Ref.	ICH model	Cells	Time after ICH	Amount	Vol (μL)	Delivery site
Bao et al[113]	Col VII	hBMSC (Flk-1+)	24 h	2 × 105	15	BP
Chen et al[120]	Col IV	ASC	48 h	3 × 106	10	LV
Fatar et al[112]	Col IV	hASC	24 h	3 × 106	500	TV
Jeon et al[110]	Col VII	ASC extract	1 h	-	-	IP
Jeong et al[138]	Col IV	hNSC	24 h	5 × 106	500	TV
Kim et al[125]	Col VII	hASC	24 h	3 × 106	2000	TV
Lee et al[126]	Col VII	hNSC	2 h; 24 h	5 × 106 (TV); 1 × 106 (IC)	500 (TV); 2 (BP)	TV; BP
Li et al[139]	Col VII	NSC	2 h; 7 h; 14 h; 21 h; 27 h	4 × 106	400	CA
Liang et al[114]	Col IV	BMSC	24 h	1 × 106	10	BP
Liao et al[66]	Col VII	hUCSC	24 h	2 × 105	10	BP
Nan et al[158]	Col VII	hUCB	24 h	2.4 × 106-3.2 × 106	500	SV
Otero et al[134]	Col IV	BMSC	72 h	2 × 106	10	BP
Otero et al[115]	Col IV	BMSC	2 m	5 × 106	15	BP
Otero et al[111]	Col IV	BMSC	2 h	2 × 106	15	BP
Qin et al[116]	Col VII	iPSC	24 h	2 × 106	10	BP
Qin et al[135]	Col VII	iPSC	24 h	1 × 106	10	BP
Seghatoleslam et al[124]	Col IV	hUCBMC	24 h	4 × 106; 8 × 106; 16 × 106	1000	TV
Seyfried et al[140]	ABI	BMSC	24 h	1 × 106	100	CA
Seyfried et al[122]	ABI	BMSC	24 h	5 × 105; 1 × 106	1000; 2000	TV
Vaquero et al[136]	Col IV	hBMSC1	2 m	5 × 106	30	BP
Wang et al[119]	Col VII	BMSC	1 h	1 × 106	1000	TV
Wang et al[137]	Col VII	NSC	72 h	1 × 106	500 (TV); 2 (BP)	TV; BP
Yang et al[121]	Col I	BMSC (overexpressing GDNF)	72 h	5 × 105	20	BP
Yang et al[117]	ABI	hUCSC	24 h; 72 h; 7 d	3 × 106	2000	TV
Yang et al[159]	Col VII	hASC	24 h	1 × 106	200	FV
Zhang et al[133]	Col VII	BMSC	24 h; 72 h; 5 d; 7 d	2 × 106	20	CA; CV; LV

¹Delivered in platelet-rich plasma scaffolds. Intracerebral hemorrhage (ICH) model: autologous blood injection (ABI) and collagenase (Col). Cell type: ASC: Adipose-derived stem cell; BMSC: Bone marrow-derived stem cell; GDNF: Glial-derived neurotrophic factor; iPSC: Induced pluripotent stem cell; UCB: Umbilical cord blood; UCBMC: Umbilical cord blood mononuclear cell; UCSC: Umbilical cord-derived stem cell; NSC: Neural stem cell. Delivery site: BP: Brain parenchyma; CA: Carotid artery; CV: Cervical vein; FV: Femoral vein; LV: Lateral ventricle; SV: Saphenous vein; TV: Tail vein.