Progress of mesenchymal stem cell therapy for neural and retinal diseases

Table 1 Registered clinical trials on mesenchymal stem cells for neural diseases

Identifier	Country	Status	Study	Phase of trial	Estimated number of patients	Estimated trial end	Disease
NCT01377870	Iran	Recruiting	Evaluation of autologous mesenchymal stem cell transplantation (effects and side effects) in multiple sclerosis	Phase 1/2	30	2013	Multiple sclerosis
NCT01895439	Jordan	Recruiting	Safety and efficacy study of autologous bone marrow mesenchymal stem cells in multiple sclerosis	Phase 1/2	30	2014	Multiple sclerosis
NCT01883661	India	Not yet recruiting	Safety and efficacy of MSCs in MS	Phase 1/2	15	2015	Multiple sclerosis
NCT00395200	United Kingdom	Completed	MSCIMS	Phase 1/2	10	2010	Multiple sclerosis
NCT01854957	Italy	Recruiting	MESEMS	Phase 1/2	20	2014	Multiple sclerosis
NCT01730547	Sweden	Recruiting	Mesenchymal stem cells for multiple sclerosis	Phase 1/2	15	2015	Multiple sclerosis
NCT01364246	China	Recruiting	Safety and efficacy of umbilical cord mesenchymal stem cell therapy for patients with progressive multiple sclerosis and neuromyelitis optica	Phase 1/2	20	2014	Multiple sclerosis
NCT01056471	Spain	Unknown	Autologous mesenchymal stem cells from adipose tissue in patients with secondary progressive multiple sclerosis (CMM/EM/2008)	Phase 1/2	30	2012	Multiple sclerosis
NCT01228266	Spain	Active, not recruiting	Mesenchymal stem cell transplantation in MS (CMM-EM)	Phase 2	16	2013	Multiple sclerosis
NCT00813969	United States	Active, not recruiting	Autologous MSC transplantation in MS	Phase 1	24	2014	Multiple sclerosis
NCT01933802	United States	Not yet recruiting	Intrathecal administration of autologous MSC-NP in patients with multiple sclerosis	Phase 1	20	2016	Multiple sclerosis
NCT01606215	United Kingdom	Recruiting	STREAMS	Phase 1/2	13	2015	Multiple sclerosis
NCT01745783	Spain	Recruiting	Mesenchymal cells from autologous bone marrow, administered intravenously in patients diagnosed with multiple sclerosis	Phase 1/2	30	2014	Multiple sclerosis
NCT00781872	Israel	Unknown	MSCs for the treatment of MS	Phase 1/2	20	2009	Multiple sclerosis
NCT01694927	Chile	Enrolling by invitation	Autologous mesenchymal stem cells in spinal cord injury (SCI) patients (MSC-SCI)	Phase 2	30	2014	Spinal cord injury
NCT01446640	China	Recruiting	Mesenchymal stem cells transplantation to patients with spinal cord injury (MSC)	Phase 1/2	20	2014	Spinal cord injury
NCT01676441	South Korea	Recruiting	Safety and efficacy of autologous mesenchymal stem cells in chronic spinal cord injury	Phase 2/3	32	2014	Spinal cord injury
NCT01769872	South Korea	Recruiting	Safety and effect of adipose tissue derived mesenchymal stem cell implantation in patients with spinal cord injury	Phase 1/2	15	2014	Spinal cord injury
NCT01162915	United States	Active, not recruiting	Transfer of bone marrow derived stem cells for the treatment of spinal cord injury	Phase 1	10	2013	Spinal cord injury
NCT01274975	South Korea	Completed	Autologous adipose derived mscs transplantation in patient with spinal cord injury	Phase 1	8	2010	Spinal cord injury
NCT01624779	South Korea	Recruiting	Intrathecal transplantation of autologous adipose tissue derived msc in the patients with spinal cord injury	Phase 1	15	2013	Spinal cord injury
NCT01393977	China	Unknown	Difference between rehabilitation therapy and stem cells transplantation in patients with spinal cord injury in China	Phase 2	60	2012	Spinal cord injury
NCT01873547	China	Recruiting	Different efficacy between rehabilitation therapy and stem cells transplantation in patients with SCI in China (SCI-III)	Phase 3	300	2014	Spinal cord injury
NCT01325103	Brazil	Unknown	Autologous bone marrow stem cell transplantation in patients with spinal cord injury	Phase 1	20	2013	Spinal cord injury
NCT00816803	Egypt	Completed	Cell transplant in spinal cord injury patients	Phase 1/2	80	2008	Spinal cord injury
NCT01343511	China	Completed	Safety and efficacy of stem cell therapy in patients with autism	Phase 1/2	37	2011	Autism

Information obtained from http://clinicaltrials.gov/. MSCs: Mesenchymal stem cells; MS: Multiple sclerosis; MSCIMS: Mesenchymal Stem Cells in Multiple Sclerosis; MESEMS: MEsenchymal StEm Cells for Multiple Sclerosis; MSC-NP: Mesenchymal Stem Cell-derived Neural Progenitors; STREAMS: Stem Cells in Rapidly Evolving Active Multiple Sclerosis.

Table 2 Registered clinical trials on mesenchymal stem cells for retinal diseases

Identifier	Country	Status	Study	Phase of trial	Estimated number of patients	Estimated trial end	Disease
NCT01531348	Thailand	Enrolling by invitation	Feasibility and safety of adult human bone marrow-derived mesenchymal stem cells by intravitreal injection in patients with retinitis pigmentosa	Phase 1	10	2014	Retinitis pigmentosa
NCT01914913	India	Not yet recruiting	Clinical study to evaluate safety and efficacy of stem cell therapy in retinitis pigmentosa	Phase 1/2	15	2015	Retinitis pigmentosa
NCT01920867	United States	Recruiting	Stem cell ophthalmology treatment study		300	2017	Glaucoma, retinitis pigmentosa, age-related macular degeneration

Information obtained from http://clinicaltrials.gov/.