Copyright ©The Author(s) 2020.
World J Stem Cells. Mar 26, 2020; 12(3): 188-202
Published online Mar 26, 2020. doi: 10.4252/wjsc.v12.i3.188
Table 1 Summary of the factors regulating Paneth cell degranulation
CytokinesIFN-γIFN-γ-dependent manner[75]Impairment of the survival of Paneth cells[76]
TNF-αTNF-α-dependent mannerPaneth cell degranulation[78]
IL-13STAT6 and PI3K/AktUpregulation of the expressions of lysozyme and MMP7[77]
IL-4Antagonizing the development process[47]Enhancing the effect of iNKT cells[79]
TLRTLR3 / 9TLR9 and TLR3 dependent mannerPaneth cell degranulation[78]
TLR4 / 5TNF-α-dependent mannerPaneth cell degranulation[78]
CD1diNKT cellsCD1d-dependentReducing the crypt lysozyme[80]
Mediating the protection against bacterial infections[80]
CholinergicPilocarpine and E. coliCD1d-dependentCrypt lysozyme intensities[80]