Copyright
©The Author(s) 2019.
World J Stem Cells. Dec 26, 2019; 11(12): 1020-1044
Published online Dec 26, 2019. doi: 10.4252/wjsc.v11.i12.1020
Published online Dec 26, 2019. doi: 10.4252/wjsc.v11.i12.1020
Table 1 Main differences of differentiation techniques based on iPSCs and direct somatic differentiation technologies
| iPSCs | Direct somatic differentiation | |
| Reprogramming time | Long | Not necessary |
| Differentiation time | Long | Brief |
| DNA instability | Occasional | Rare |
| Proliferation of pre-differentiated cells | High (iPSCs) | Low (e.g., fibroblasts) |
| Self-renewal of pre-differentiated cells | Yes (iPSCs) | No (e.g., fibroblasts) |
| Heterogenicity of the differentiated population | Critical | Critical |
- Citation: Genova E, Cavion F, Lucafò M, Leo LD, Pelin M, Stocco G, Decorti G. Induced pluripotent stem cells for therapy personalization in pediatric patients: Focus on drug-induced adverse events. World J Stem Cells 2019; 11(12): 1020-1044
- URL: https://www.wjgnet.com/1948-0210/full/v11/i12/1020.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v11.i12.1020