Copyright ©The Author(s) 2018.
World J Stem Cells. Nov 26, 2018; 10(11): 146-159
Published online Nov 26, 2018. doi: 10.4252/wjsc.v10.i11.146
Table 1 Relationship between immunomodulatory protein secreted by adipose-derived mesenchymal stem cells and liver cirrhosis
PROT IDDescriptionReference
FINCFibronectinFibronectin expression is critical for liver fibrogenesis in vivo and in vitro[74]
CO1A2Collagen alpha-2(I) chainN/A
CO1A1Collagen alpha-1(I) chainType I collagen has also been reported to be one of the components of hepatic fibrosis[73]
CATBCathepsin BN/A
TSP1Thrombospondin-1TSP1 might contribute to liver fibrosis not only as an activator of TGF-β, but also as an modulator of angiogenesis[75]
CFAHComplement factor HN/A
GAS6Growth arrest-specific protein 6Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation[77]
PTX3Pentraxin-related protein PTX3The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling[78]
C1SComplement C1s subcomponentN/A
G3PGlyceraldehyde-3-phosphate dehydrogenaseN/A
PXDNPeroxidasin homologN/A
SRCRLSoluble scavenger receptor cysteine-rich domain-containing protein SSC5DN/A
CD248EndosialinCD248 reduces susceptibility to liver fibrosis via an effect on PDGF signalling[79]
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2N/A
CD109CD109 antigenN/A
CFABComplement factor BN/A
CATL1Cathepsin L1N/A
MFAP5Microfibrillar-associated protein 5N/A
MIFMacrophage migration inhibitory factorMIF exerts antifibrotic effects in experimental liver fibrosis via CD74[80]
CXCL5C-X-C motif chemokine 5Plasma CXCL5 levels in patients with liver cirrhosis were lower than in healthy controls[81,82]
ADAM9Disintegrin and metalloproteinase domain-containing protein 9N/A
CATKCathepsin KN/A
Table 2 Relationship between angiogenesis protein secreted by adipose-derived mesenchymal stem cells and liver cirrhosis
PROT IDDescriptionReference
PAI1Plasminogen activator inhibitor 1PAI-1 regulates angiogenesis via effects on extracellular matrix proteolysis and cell adhesion[87]
FSTL1Follistatin-related protein 1Knockdown of Fstl1 attenuates hepatic stellate cell activation through the TGFβ1/Smad3 signaling pathway[88]
POSTNPeriostinPOSTN, a ligand of αvβ3/5 integrins, as an effector protein in SULF2-induced angiogenesis[89]
MMP272 kDa type IV collagenaseMMP2 has an important role in the preservation of liver vascular homeostasis[91]
TSP1Thrombospondin-1TSP1 was reported to be increased in HSCs isolated from the liver of CCl4-induced cirrhosis model mice[92]
TIMP1Metalloproteinase inhibitor 1Inhibition of TIMP1 was reported to promote angiogenesis by increasing cell motility during fibrovascular invasion[93]
FBLN3EGF-containing fibulin-like extracellular matrix protein 1FBLN3 has been reported as an angiogenesis antagonist regulating cell morphology, growth, adhesion and motility[95]
MFGMLactadherinMFGM promote angiogenesis via enhanced PDGF-PDGFRβ signaling mediated by cross-talk of the integrin growth factor receptor[97]