Copyright ©The Author(s) 2021.
World J Stem Cells. Mar 26, 2021; 13(3): 221-235
Published online Mar 26, 2021. doi: 10.4252/wjsc.v13.i3.221
Table 1 Human induced pluripotent stem cells models used to study insulin resistance
Disease/ syndrome
iPSC models
Main findings
Iovino et al[69]DS with severe insulin resistanceThree different INSR mutations (patient-derived iPSCs): (1) Compound heterozygous A897X, exon 14; (2) Homozygous A2G, exon 1; (3) Homozygous L233P, exon 3iPSCs generated from patients with severe IR showed defects in the self-renewal of the patient-derived iPSCs
Balhara et al[67]Patient-derived iPSCs with a compound heterozygous mutation in exon 14 of INSR (A897X)Mesenchymal progenitor cells (MPCs) generated from patient-derived iPSCs showed defects in the insulin signaling pathway and the cellular oxidative metabolism
Burkart et al[68]Four different INSR mutations (patient-derived iPSCs): (1) Compound heterozygous A897X, exon 14; (2) Homozygous (A2G), exon 1; (3) Homozygous (L233P), exon 3; (4) Homozygous (E124X), exon2INSR-Mut hiPSCs have an impairment in the energy homeostasis as well as dysregulation of oxidative metabolism
Iovino et al[66]Skeletal myotubes derived from INSR-Mut hiPSCs exhibit defects in insulin signaling, glucose uptake, and glycogen accumulation and altered insulin signaling gene expression
Mori et al[74]Congenital generalized lipodystrophy(CGL)Two different BSCL2 mutations (patient-derived iPSCs): (1) Homozygous (E189X), exon 5; (2) Homozygous (R275X), exon 8The adipose tissue derived from BSCL2-Mut hiPSCs exhibit notably a decrease in the lipid droplet formation as well as diffuse cytoplasmic distribution of ADRP
Friesen et al[75]Familial partial lipodystrophy type 2 (FPLD2)Heterozygous mutation in exon 1 of LMNA gene (R28W) (patient-derived iPSCs)FPLD2-iPSCs recapitulate insulin resistance phenotypes and have lower capability for adipogenic differentiation with functional deficiency
Jozefczuk et al[78]Insulin resistant patients with liver steatosisPatient-derived iPSCsiPSCs derived from IR patients recapitulate insulin resistance and showed a decrease in AKT/mTOR signaling pathway and perturbed various cellular networks
Ali et al[79]Patients with psoriasis and insulin resistancePatient-derived iPSCsiPSCs-derived keratinocytes showed genetic alterations in the transcripts associated with IR, including IRS2 and GDF15 and glucose transporters, GLUT10 and GLUT14
Carcamo-Orive et al[82]Insulin resistant patientsPatient-derived iPSCsiPSCs derived from IR and IS individuals uncovered several IR relevant networks and identified a set of IR related driver genes