Copyright ©The Author(s) 2020.
World J Stem Cells. Sep 26, 2020; 12(9): 986-1000
Published online Sep 26, 2020. doi: 10.4252/wjsc.v12.i9.986
Table 1 Effects of neuropeptide Y receptor-targeted drugs on bone metabolism
AntagonistBone phenotypeAdministration and subjects
Y1R antagonist BIBP3226[56]Callus tissue volume ↓, callus bone volume and callus ↓, BV/TV↓Intraperitoneal injection
Sprague-Dawley rats
Y2R antagonist JNJ-31020028[79]Vertebral trabecular bone volume ↑, bone mineral density ↑, trabecular thickness ↑; P1NP and CTX biomarkers ↓Intraperitoneal injection
Ovariectomized Mice
Y1R antagonist BIBO3304[80]Osteoblast activity ↑, cortical and cancellous bone volumes ↑; no adverse effectsOral administration