Copyright ©The Author(s) 2020.
World J Stem Cells. Sep 26, 2020; 12(9): 922-937
Published online Sep 26, 2020. doi: 10.4252/wjsc.v12.i9.922
Table 1 Influence of inflammatory priming on immunomodulatory features of mesenchymal stromal/stem cells under in vitro conditions
Priming factorMSCs sourceImmunomodulatory effects of inflammatory primingSuggested mechanismRef.
Pro-inflammatory cytokinesIFN-γhWJ-MSCs↓ Th1 and Th17 cells proliferation↑ CXCL9, CXCL10, CXCL11, ICAM-1, VCAM-1, IDO1 and HLA-G5 gene expressionWang et al[35], 2016
↑ Th2 and Tregs (CD4+, CD25+, CD127dim/− cells) percentage↓ IFNγ, TNFα but ↑ IL-10 and IL-6 secretion in co-culture with PB-MNCs
hBM-MSCs↓ T-cell effector functions and Th1 cytokine (IFN-γ, TNF-α, and IL-2) production↑ B7H1 and B7DC (ligands for PD1) expressionChinnadurai et al[36], 2014
IFN-γ and TNF-αhBM-MSCs↓ T cell proliferation↑ IDO activityFrançois et al[55], 2012
↑ Monocyte differentiation into M2 (IL-10-secreting CD206+) immunosuppressive macrophages
↓ CD3/CD28-induced T-cell proliferation↓ Potency to trigger increased IFN-γ and IL-2 synthesis by activated T cellsCuerquis et al[59], 2014
TNF-α/IFN-γ and IL-βrBM-MSCs↓ Proliferation of syngeneic lymphocytes↑ NO productionMurphy et al[80], 2019
IL-17hBM-MSCs↓ PHA-stimulated T-cell proliferation↑ IL-6 gene expressionSivanathan et al[94], 2015
↓ Expression of CD25 on CD4+ effector T cellsTreg-mediated IL-2 deprivation
↓ T cell effector function and Th1 cytokines (IFN-γ, TNF-α, IL-2) secretion
↑ Formation of Tregs (CD4+ CD25 high CD127 low FoxP3+)Cell-contacts and ↑ PGE2 and TGF-β expression
IFN-γ, TNF-α and IL-17mBM-MSC↓ T-cell proliferation↑ iNOS expressionHan et al [95], 2014
IFN-γ, TNF-α and IL-6hAT-MSC↓ Proliferation of PHA or MLR activated PB-MNCs↑ IDO expressionCrop et al[111], 2010
AlarminsIL-1αhBM-MSCs↓ IL-6, TNF-α and ↑ IL-10 secretion in LPS-activated mouse microglial BV2 cells↑ G-CSF secretionRedondo-Castro et al[78], 2017
HMGB1hBM-MSCUnaffected inhibition of Con A-induced lymphocyte proliferation/Meng et al[118], 2008