Copyright ©The Author(s) 2020.
World J Stem Cells. Aug 26, 2020; 12(8): 814-840
Published online Aug 26, 2020. doi: 10.4252/wjsc.v12.i8.814
Table 3 Clinical studies with mesenchymal stem cell-derived exosomes
Study titleDiseaseInterventionPhaseNCT
Allogenic mesenchymal stem cell derived exosome in patients with acute ischemic strokeCerebrovascular disordersBiological: ExosomeCompletedNCT03384433
A pilot clinical study on inhalation of mesenchymal stem cells exosomes treating severe novel coronavirus pneumoniaCoronavirusBiological: MSCs-derived exosomesPhase 1NCT04276987
Effect of microvesicles and exosomes therapy on β-cell mass in type I diabetes mellitus (T1DM)Diabetes mellitus type 1Biological: MSC ExosomesPhase 2, Phase 3NCT02138331
iExosomes in treating participants with metastatic pancreas cancer with KrasG12D mutationMetastatic pancreatic adenocarcinomaDrug: Mesenchymal stromal cells-derived exosomes with KRAS G12D siRNAPhase 1NCT03608631
Effect of UMSCs Derived exosomes on dry eye in patients with cGVHDDry eyeDrug: Umbilical mesenchymal stem cells derived exosomesPhase 1, Phase 2NCT04213248
Evaluation of adipose derived stem cells treatment of periodontitisPeriodontitisBiological: Adipose derived stem cells exosomesEarly phase 1NCT04270006
A tolerance clinical study on aerosol inhalation of mesenchymal stem cells exosomes in healthy volunteersHealthyBiological: Low level of MSCs-Exo Biological: High level of MSCs-ExoPhase 1NCT04313647
MSC-Exos promote healing of MHsMacular holesBiological: Exosomes derived from mesenchymal stem cells (MSC-Exo)Early Phase 1NCT03437759