Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine

Table 3 Clinical studies with mesenchymal stem cell-derived exosomes

Study title	Disease	Intervention	Phase	NCT
Allogenic mesenchymal stem cell derived exosome in patients with acute ischemic stroke	Cerebrovascular disorders	Biological: Exosome	Completed	NCT03384433
A pilot clinical study on inhalation of mesenchymal stem cells exosomes treating severe novel coronavirus pneumonia	Coronavirus	Biological: MSCs-derived exosomes	Phase 1	NCT04276987
Effect of microvesicles and exosomes therapy on β-cell mass in type I diabetes mellitus (T1DM)	Diabetes mellitus type 1	Biological: MSC Exosomes	Phase 2, Phase 3	NCT02138331
iExosomes in treating participants with metastatic pancreas cancer with KrasG12D mutation	Metastatic pancreatic adenocarcinoma	Drug: Mesenchymal stromal cells-derived exosomes with KRAS G12D siRNA	Phase 1	NCT03608631
Effect of UMSCs Derived exosomes on dry eye in patients with cGVHD	Dry eye	Drug: Umbilical mesenchymal stem cells derived exosomes	Phase 1, Phase 2	NCT04213248
Evaluation of adipose derived stem cells exo.in treatment of periodontitis	Periodontitis	Biological: Adipose derived stem cells exosomes	Early phase 1	NCT04270006
A tolerance clinical study on aerosol inhalation of mesenchymal stem cells exosomes in healthy volunteers	Healthy	Biological: Low level of MSCs-Exo Biological: High level of MSCs-Exo	Phase 1	NCT04313647
MSC-Exos promote healing of MHs	Macular holes	Biological: Exosomes derived from mesenchymal stem cells (MSC-Exo)	Early Phase 1	NCT03437759