Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues

Figure 6 Cytokine and trophic factor expression through Multiplex ELISA analysis in supernatants after cell culture of bone marrow - mesenchymal stem cells, adipose tissue - mesenchymal stem cells, skeletal muscle - mesenchymal stem cells and skin - mesenchymal stem cells. MCP-1 was detected in all supernatants; however, statistical significance was only proven in BM-MSCs and SM-MSCs. The highest concentration of IL-6 was observed in supernatants after AT-MSC culture. In the supernatants of all examined MSCs, a low concentration of IL-5 and IFN-γ was observed. The highest concentrations of VEGF and IL-8 were observed in supernatants from the BM-MSC culture; however, smaller amounts of VEGF and IL-8 were also detected in the later passages in AT-MSCs and SM-MSCs. (^*P < 0.05, ^**P < 0.001). BM-MSC: Bone marrow - mesenchymal stem cell; AT-MSC: Adipose tissue - mesenchymal stem cell; SK-MSC: Skin - mesenchymal stem cell; SM-MSC: Skeletal muscle - mesenchymal stem cell.