Copyright ©The Author(s) 2019.
World J Stem Cells. Jun 26, 2019; 11(6): 297-321
Published online Jun 26, 2019. doi: 10.4252/wjsc.v11.i6.297
Table 2 Electromagnetic field studies
Electromagnetic fieldsConditionsBiological effectsReferences number
Extremely low-frequency pulsed magnetic fieldsAdult ventricular cardiomyocytesInduction of the expression of endorphin genes and peptides; Control of intracellular calcium and pH homeostasis; Regulation of myocardial growth; Orchestration of stem cell cardiogenesis[101-109]
Mouse embryonic stem (ES) cellsInduction of cardiogenesis, cardiac gene and protein expression, ensuing into a high-throughput of spontaneously beating cardiomyocytes[110]
Radioelectric field of 2.4 GHz (REAC)Mouse ES cells, hADSCs and human skin fibroblastsOptimization in the expression of pluripotency/multipotency; Increase in commitment along myocardial, skeletal muscle, and neuronal fates, with a biphasic effect on the transcription of stemness genes[111-117]
hADSCsReduction of senescence-associated β-galactosidase expression; Overexpression of the TERT gene associated with an increase in telomerase activity; Overexpression of the BMI1 gene; REAC effects counteracted by chemical inhibition of type-2 hyaluronan synthase[118-120]
PC12 cells, a rat cell line of pheochromocytomaInduction of the neurological and morphofunctional differentiation; Up-regulation of neurogenic genes; Decrease in PC12 cells[132]