Copyright ©The Author(s) 2019.
World J Stem Cells. May 26, 2019; 11(5): 236-253
Published online May 26, 2019. doi: 10.4252/wjsc.v11.i5.236
Table 1 Advantages and disadvantages of different systems for modelling Alzheimer’s disease[178]
Model systemAdvantagesDisadvantages
Animal modelsCan be used to model physiological factors such as diet, obesity and hypertensionFindings may not be able to be directly extrapolated to humans
Postmortem tissueHuman-derivedDifficult to obtain; May be of poor quality due to the destructive effects of AD in its later stages
iPSC-based modelsHuman-derived; More easily obtained than post-mortem tissueCannot be used to model physiological or epigenetic factors; Large variation between sAD iPSC lines (may not exhibit phenotype); Neuronal derivatives may be akin to ‘younger’ neurons