Copyright ©The Author(s) 2018.
World J Stem Cells. Nov 26, 2018; 10(11): 146-159
Published online Nov 26, 2018. doi: 10.4252/wjsc.v10.i11.146
Table 2 Relationship between angiogenesis protein secreted by adipose-derived mesenchymal stem cells and liver cirrhosis
PROT IDDescriptionReference
PAI1Plasminogen activator inhibitor 1PAI-1 regulates angiogenesis via effects on extracellular matrix proteolysis and cell adhesion[87]
FSTL1Follistatin-related protein 1Knockdown of Fstl1 attenuates hepatic stellate cell activation through the TGFβ1/Smad3 signaling pathway[88]
POSTNPeriostinPOSTN, a ligand of αvβ3/5 integrins, as an effector protein in SULF2-induced angiogenesis[89]
MMP272 kDa type IV collagenaseMMP2 has an important role in the preservation of liver vascular homeostasis[91]
TSP1Thrombospondin-1TSP1 was reported to be increased in HSCs isolated from the liver of CCl4-induced cirrhosis model mice[92]
TIMP1Metalloproteinase inhibitor 1Inhibition of TIMP1 was reported to promote angiogenesis by increasing cell motility during fibrovascular invasion[93]
FBLN3EGF-containing fibulin-like extracellular matrix protein 1FBLN3 has been reported as an angiogenesis antagonist regulating cell morphology, growth, adhesion and motility[95]
MFGMLactadherinMFGM promote angiogenesis via enhanced PDGF-PDGFRβ signaling mediated by cross-talk of the integrin growth factor receptor[97]