Letter to the Editor: Exosomal circular RNAs from peripheral blood-derived mesenchymal stem cells as diagnostic and subtyping biomarkers in acute mesenteric ischemia

Figure 1 Diagnostic utility of peripheral blood-derived mesenchymal stem cell-exosomal circular RNAs in acute mesenteric ischemia. The clinical significance of peripheral blood-derived mesenchymal stem cell exosomal circular RNAs is rooted in their covalent closed-loop structure, which provides inherent stability and resistance to RNase-mediated degradation compared with linear mRNA. These biomarkers function as dual indicators, simultaneously reflecting the severity of enterocyte damage and the systemic inflammatory burden associated with acute mesenteric ischemia. Furthermore, their differential expression patterns allow for precise surgical triage by distinguishing early reversible ischemia from advanced necrotic acute mesenteric ischemia, thereby identifying critical surgical urgency. Created in BioRender (Supplementary material). MSCs: Mesenchymal stem cells; circRNAs: Circular RNAs; AMI: Acute mesenteric ischemia.