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For: Pulido-Escribano V, Torrecillas-Baena B, Camacho-Cardenosa M, Dorado G, Gálvez-Moreno MÁ, Casado-Díaz A. Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles. World J Stem Cells 2022; 14(7): 453-472 [PMID: 36157530 DOI: 10.4252/wjsc.v14.i7.453]
URL: https://www.wjgnet.com/1948-0210/full/v14/i7/453.htm
Number Citing Articles
1
Nhung Thi-Hong Dinh, Quyen Thi Nguyen, Ngo Thu Hang, Hong-Nhung Dao, Le Duc Son, Giang Trang Ngan, Can Van Mao, Xuan-Hai Do, Van T. Hoang, Liem Nguyen Thanh. Assessment of the safety of hypoxia-primed mesenchymal stem cells derived from umbilical cord and adipose tissues in animals. Scientific Reports 2025; 15(1) doi: 10.1038/s41598-025-20018-5
2
Akinleye Stephen Akinrinde, Ekundayo Stephen Samuel, Bisi Olajumoke Adeoye. Dose-dependent effects of cobalt chloride supplementation in a rat model of acetic acid-induced ulcerative colitis. Comparative Clinical Pathology 2024; 33(5) doi: 10.1007/s00580-024-03586-2
3
Xinling Luo, Weiqi Zeng, Erfeng Xiong, Ziming Wang, Jingsheng Huang, Meiqi Luo, Zhongxian He, Jinyu Liu, Dongdong Yuan. Hypoxia-preconditioning human bone marrow-derived mesenchymal stem cells induce high-quality mitochondrial transfer through gap junctions to alleviate ischemia-reperfusion injury in liver graft. Cell Communication and Signaling 2025; 23(1) doi: 10.1186/s12964-025-02497-1
4
Wei Bian, Xiangyu Zeng, Ziwen Liu, Mingyan Guan, Tegeleqi Bu, Haoze Li, Zewei Gao, Jianyu Liu. Hypoxia-conditioned BMSC exosomes improve short-term spinal cord injury outcomes via the miR-615-3p/PDE4C-mediated cAMP/PKA pathway. Stem Cell Research & Therapy 2026; 17(1) doi: 10.1186/s13287-026-04895-9
5
Fatima Jameel, Iqra Sahibdad, Sidra Ghulam Muhammad, Asmat Salim. Wound pathophysiology and healing dynamics for stem cell-mediated therapeutics in different skin wounds. World Journal of Stem Cells 2026; 18(3): 115658 doi: 10.4252/wjsc.v18.i3.115658
6
Gordana Velikic, Gordana Supic, Dusica L. Maric, Miljan Puletic, Marija D. Maric, Branko Barac, Dusan M. Maric. Stem Cell and Exosome Therapy in Wound Healing: Traps, Paradoxes, and Tricks Transforming Paradigms. Biomedicines 2025; 13(12) doi: 10.3390/biomedicines13123030
7
Vitale Miceli, Giovanni Zito, Matteo Bulati, Alessia Gallo, Rosalia Busà, Gioacchin Iannolo, Pier Giulio Conaldi. Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells: Potential implications for their clinical use. World Journal of Stem Cells 2023; 15(5): 400-420 doi: 10.4252/wjsc.v15.i5.400
8
Cuc Huynh, Ngoc Vu, Trung Van, Phuc Pham. Effects of Exosomes From Hypoxia-Induced Adipose-Derived Stem Cells on Ameliorating Photoaging. Clinical, Cosmetic and Investigational Dermatology 2025;  doi: 10.2147/CCID.S523936
9
Ayesha Nisar, Sawar Khan, Wen Li, Li Hu, Priyadarshani Nadeeshika Samarawickrama, Naheemat Modupeola Gold, Meiting Zi, Sardar Azhar Mehmood, Jiarong Miao, Yonghan He. Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targets. MedComm 2024; 5(11) doi: 10.1002/mco2.786
10
Renata Trabach Santos, Cássia Lisboa Braga, Maria Eduarda de Sá Freire Onofre, Carla Medeiros da Silva, Nazareth de Novaes Rocha, Rodrigo Gonzaga Veras, Sabrina Sodré de Souza Serra, Douglas Esteves Teixeira, Sarah Aparecida dos Santos Alves, Beatriz Toja Miranda, Miria Gomes Pereira, Celso Caruso Neves, Monique Ramos de Oliveira Garcia, Christina Maeda Takiya, Patricia Rieken Macêdo Rocco, Fernanda Ferreira Cruz, Pedro Leme Silva. Cardioprotective effects of extracellular vesicles from hypoxia-preconditioned mesenchymal stromal cells in experimental pulmonary arterial hypertension. Stem Cell Research & Therapy 2025; 16(1) doi: 10.1186/s13287-025-04604-y
11
Yasaman Nazerian, Amirhossein Nazerian, Fereshteh Mohamadi-Jahani, Parastoo Sodeifi, Maryam Jafarian, Seyed Amir Hossein Javadi. Hydrogel-encapsulated extracellular vesicles for the regeneration of spinal cord injury. Frontiers in Neuroscience 2023; 17 doi: 10.3389/fnins.2023.1309172
12
Ramiro A. Villarreal-Leal, Oscar S. Velazquez, Beck Burgelin, Robin S. Vander Pol, Corrine Ying Xuan Chua, R. Steven Conlan, Richard H. Finnell, Alessandro Grattoni, Bruna Corradetti. Inflammatory Preconditioning Reprograms Mesenchymal Stromal Cell-Derived Extracellular Vesicles into Distinct Functional States for Immunomodulation and Wound Healing. Stem Cells and Development 2026; 35(13-14) doi: 10.1177/15473287261456137
13
O. V. Zhidkova, E. R. Andreeva, L. B. Buravkova. Activated Endothelium Stimulates the Activity of Multipotent Mesenchymal Stromal Cells under Physiological Hypoxia or Short-Term Hypoxic Stress in vitro. Journal of Evolutionary Biochemistry and Physiology 2024; 60(2) doi: 10.1134/S0022093024020194
14
Alessia Dallatana, Linda Cremonesi, Francesco Pezzini, Gianluca Fontana, Giulio Innamorati, Luca Giacomello. The Placenta as a Source of Human Material for Neuronal Repair. Biomedicines 2024; 12(7) doi: 10.3390/biomedicines12071567
15
Jinxin Zhang, Xingchen Wei, Na Han. Reprogramming the Aging Type H Vascular Niche via Myeloid Angiogenic Cell-Derived Extracellular Vesicles: Mechanisms, Engineering Strategies, and Translational Perspectives. International Journal of Molecular Sciences 2026; 27(18) doi: 10.3390/ijms27188202
16
Lijuan Zheng, Hui Gong, Jing Zhang, Linna Guo, Zhuofan Zhai, Shuang Xia, Zhiyu Hu, Jing Chang, Yizhu Jiang, Xinran Huang, Jingyi Ge, Bikui Zhang, Miao Yan. Strategies to improve the therapeutic efficacy of mesenchymal stem cell‐derived extracellular vesicle (MSC-EV): a promising cell-free therapy for liver disease. Frontiers in Bioengineering and Biotechnology 2023; 11 doi: 10.3389/fbioe.2023.1322514
17
Vitale Miceli. Priming strategies to enhance the therapeutic efficacy of mesenchymal stromal/stem cell-derived vesicles in regenerative medicine. Extracellular Vesicles and Circulating Nucleic Acids 2026; 7(1) doi: 10.20517/evcna.2025.84
18
Su-Min Park, Yong-Hun Oh, Ga-Hyun Lim, Ga-Hee Yun, Kyung-Bo Kim, Ju-Hyun An, Kyung-Won Seo, Hwa-Young Youn. Deferoxamine preconditioning of canine stem cell derived extracellular vesicles alleviates inflammation in an EAE mouse model through STAT3 regulation. Scientific Reports 2024; 14(1) doi: 10.1038/s41598-024-68853-2
19
Eugenio Caradonna, Francesco Setacci, Jessica Lanza, Fulvio Ferrara, Carlo Setacci, Massimo Danese, Gaetano Lanza. Autologous Cell Therapy for Chronic Limb Threatening Ischemia: Towards Personalized Medicine. Angiology 2026; 77(8) doi: 10.1177/00033197251376093
20
Siyi Xie, Meiling Liu, Yajie Kong, Yiming Yang, Ruixue Chen, Yuzhong Wang, Shuxing Cao, Yongzhou Song. Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus. Frontiers in Cell and Developmental Biology 2025; 13 doi: 10.3389/fcell.2025.1549096
21
Joshua B. Stein, Songzi Zhang, Eun Ji Roh, Jeffrey Luo, Meizi Chen, Hyunjun Jang, Li Ling Goldston, Brandon Conklin, Inbo Han, Ki‐Bum Lee. Advanced Biomaterial Delivery of Hypoxia‐Conditioned Extracellular Vesicles (EVs) as a Therapeutic Platform for Traumatic Brain Injury. Advanced Science 2025; 12(44) doi: 10.1002/advs.202504147
22
M. I. Ezdakova, D. K. Matveeva, I. V. Andrianova, E. R. Andreeva. The Sensitivity of Multipotent Mesenchymal Stromal Cells to Short-Term Hypoxic Stress In Vitro Depends on the Efficiency of Homotypic Communication through Gap Junctions. Moscow University Biological Sciences Bulletin 2023; 78(3) doi: 10.3103/S0096392523700086
23
Khawaja Husnain Haider. Priming mesenchymal stem cells to develop “super stem cells”. World Journal of Stem Cells 2024; 16(6): 623-640 doi: 10.4252/wjsc.v16.i6.623
24
O. V. Zhidkova, E. R. Andreeva, L. B. Buravkova. Activated Endothelium Changes The Activity Of Multipotent Mesenchymal Stromal Cells During Physiological Hypoxia Or Short Hypoxic Stress In Vitro. Российский физиологический журнал им  И  М  Сеченова 2024; 110(3) doi: 10.31857/S0869813924030086
25
Ziyang Ye, Wenjie Chen, Genpeng Li, Jing Huang, Jianyong Lei. Tissue-derived extracellular vesicles in cancer progression: mechanisms, roles, and potential applications. Cancer and Metastasis Reviews 2024; 43(2) doi: 10.1007/s10555-023-10147-6
26
Nada Serhal, Bertrand Brassart, Lise Nannan, Sandra Audonnet, Christine Terryn, Gaël Poitevin, Pascale Cornillet‐Lefebvre, Florine Dubuisson, Hélène Peyret, Philippe Nguyen, Claire Tournois. Angiogenic Potential of Small Extracellular Vesicles Produced by Stimulated Mesenchymal Stromal Cells Under Hypoxic Conditions. Journal of Extracellular Biology 2026; 5(1) doi: 10.1002/jex2.70105
27
Flor Negrete-Diaz, Sofia Martinez-Rodriguez, Atocha Guedan-Duran, Andrea Romero-Lopez, Fivos Panetsos. MSC secretomes as a cell-free therapeutic platform: Molecular heterogeneity, disease-specific bioactivity, delivery strategies, and regulatory translation across six major disease areas. Pharmacological Research 2026; 230 doi: 10.1016/j.phrs.2026.108245
28
Magdalena Strecanska, Tatiana Sekelova, Maria Csobonyeiova, Lubos Danisovic, Michaela Cehakova. Therapeutic applications of mesenchymal/medicinal stem/signaling cells preconditioned with external factors: Are there more efficient approaches to utilize their regenerative potential?. Life Sciences 2024; 346 doi: 10.1016/j.lfs.2024.122647
29
Sharif A. Sabe, Cynthia M. Xu, Brittany A. Potz, Akshay Malhotra, Mohamed Sabra, Dwight D. Harris, Mark Broadwin, M. Ruhul Abid, Frank W. Sellke. Comparative Analysis of Normoxia- and Hypoxia-Modified Extracellular Vesicle Therapy in Function, Perfusion, and Collateralization in Chronically Ischemic Myocardium. International Journal of Molecular Sciences 2023; 24(3) doi: 10.3390/ijms24032076
30
Golara Nasiri, Parinaz Mofazali, Aliakabar Alizadeh, Ali Babaeizad, Jeffrey D. Gross, Ali Samadi. Advanced Hydrogel Architectures for Neural Tissue Engineering: Design, Mechanisms of Functional Recovery, and Emerging Patent Trends. Colloids and Surfaces B: Biointerfaces 2026;  doi: 10.1016/j.colsurfb.2026.116194
31
Narjes Seddighi, Mehdi Talebi, Karim Shamsasenjan, Mortaza Raeisi, AliAkbar Movassaghpour. Pro-tumorigenic effects and therapeutic implications of mesenchymal stem cell-derived exosomes under hypoxic conditions: a systematic review. Discover Oncology 2026; 17(1) doi: 10.1007/s12672-025-04279-0
32
Na Liu, Xue Zhao, Xicai Sun, Yongmei Liu, Jing Xu, Donghua Xu, Wenchang Sun. Mesenchymal stem cells-derived extracellular vesicles as a novel drug delivery carrier: engineering strategies and clinical safety estimation. Frontiers in Molecular Biosciences 2026; 13 doi: 10.3389/fmolb.2026.1838554
33
Benshuai You, Chenglin Zhou, Yang Yang. MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis. Ageing Research Reviews 2023; 85 doi: 10.1016/j.arr.2023.101864
34
Silvia Peppicelli, Lido Calorini, Francesca Bianchini, Laura Papucci, Lucia Magnelli, Elena Andreucci. Acidity and hypoxia of tumor microenvironment, a positive interplay in extracellular vesicle release by tumor cells. Cellular Oncology 2025; 48(1) doi: 10.1007/s13402-024-00969-z
35
Marta Camacho-Cardenosa, Victoria Pulido-Escribano, Bárbara Torrecillas-Baena, Jose Manuel Quesada-Gómez, Aura D. Herrera-Martínez, Rafael R. Sola-Guirado, Gabriel Dorado, María Ángeles Gálvez-Moreno, Antonio Casado-Díaz. Combined Effects of Cyclic Hypoxic and Mechanical Stimuli on Human Bone Marrow Mesenchymal Stem Cell Differentiation: A New Approach to the Treatment of Bone Loss. Journal of Clinical Medicine 2024; 13(19) doi: 10.3390/jcm13195805
36
Victoria Pulido-Escribano, Marta Camacho-Cardenosa, Gabriel Dorado, José Manuel Quesada-Gómez, Alfonso Calañas-Continente, María Ángeles Gálvez-Moreno, Antonio Casado-Díaz. The Use of Plant-Derived Extracellular Vesicles in Regenerative Medicine Applied to Cutaneous Wound Healing. Pharmaceutics 2025; 17(12) doi: 10.3390/pharmaceutics17121531
37
Antonio Casado-Díaz. Stem Cells in Regenerative Medicine. Journal of Clinical Medicine 2022; 11(18) doi: 10.3390/jcm11185460
38
Li Chen, Yang Yang, Junwei Chen, Yinghong Lin, Liang Xian, Yuhui Chen, Xingshu Zhu, Ying Tang, Yi Zuo, Shaohuai Xia, Xuewei Xia, Yongjun Xu, Shousen Wang. Intranasal delivery of hypoxia-preconditioned extracellular vesicles derived from BMSCs alleviates neuroinflammation and brain dysfunction in TBI. Stem Cell Research & Therapy 2025; 16(1) doi: 10.1186/s13287-025-04572-3
39
Dwight D. Harris, Sharif A. Sabe, Mark Broadwin, Christopher Stone, Cynthia Xu, Meghamsh Kanuparthy, Akshay Malhotra, M. Ruhul Abid, Frank W. Sellke. Intramyocardial injection of hypoxia-conditioned extracellular vesicles increases myocardial perfusion in a swine model of chronic coronary disease. JTCVS Open 2024; 20 doi: 10.1016/j.xjon.2024.06.003
40
Hon‐Lok Lo, Shih‐Hao Huang, Ting‐Hsuan Dai, Shun‐Cheng Wu, Cheng‐Jung Ho, Cheng‐Chang Lu. Extracellular Vesicle‐Mediated Communication Between Anterior Cruciate Ligament and Bone Marrow Cells Modulates Hamstring Tenocyte Behavior and Apoptosis. The Kaohsiung Journal of Medical Sciences 2026; 42(8) doi: 10.1002/kjm2.70176
41
Supeng Wang, Zhiqiang Jia, Minghai Dai, Xujun Feng, Chengxuan Tang, Liangle Liu, Lingling Cao. Advances in natural and synthetic macromolecules with stem cells and extracellular vesicles for orthopedic disease treatment. International Journal of Biological Macromolecules 2024; 268 doi: 10.1016/j.ijbiomac.2024.131874
42
Cássia Lisboa Braga, Renata Trabach Santos, Carla Medeiros da Silva, Nazareth de Novaes Rocha, Nathane Santanna Felix, Mayck Medeiros, Monique Martins Melo, Johnatas Dutra Silva, Douglas Esteves Teixeira, Celso Caruso Neves, Patricia Rieken Macedo Rocco, Fernanda Ferreira Cruz, Pedro Leme Silva. Therapeutic effects of hypoxia-preconditioned bone marrow-derived mesenchymal stromal cells and their extracellular vesicles in experimental pulmonary arterial hypertension. Life Sciences 2023; 329 doi: 10.1016/j.lfs.2023.121988
43
Mohini Mendiratta, Meenakshi Mendiratta, Sujata Mohanty, Hridayesh Prakash, Lakshay Malhotra, Sandeep Rai, Vijaya Sarangathem, Sabyasachi Bandyopadhyay, GuruRao Hariprasad, Ritu Gupta, Sameer Bakhshi, Vatsla Dadhwal, Deepam Pushpam, Mukul Aggarwal, Aditya Kumar Gupta, Prabhat Singh Malik, Raja Pramanik, Manoranjan Mahapatra, Tulika Seth, Rishi Dhawan, Baibaswata Nayak, Thoudam Debraj Singh, Sachin Kumar, Riyaz Ahmed Mir, Surender Kumar Sharawat, Ranjit Kumar Sahoo. Hypoxia-induced metabolic and apoptotic reprogramming enhances immunomodulation in Wharton’s jelly mesenchymal stem cells. iScience 2026; 29(4) doi: 10.1016/j.isci.2026.115363
44
Wendy V. Jaraba-Álvarez, Ashanti C. Uscanga-Palomeque, Vanesa Sanchez-Giraldo, Claudia Madrid, Hector Ortega-Arellano, Karolynn Halpert, Carolina Quintero-Gil. Hypoxia-induced metabolic reprogramming in mesenchymal stem cells: unlocking the regenerative potential of secreted factors. Frontiers in Cell and Developmental Biology 2025; 13 doi: 10.3389/fcell.2025.1609082
45
Wei Li, Xu Chen, Feng Zou, Xiaotong He. Extracellular Vesicles Derived From Hypoxia-Treated Human Adipose Stem Cells Increase Proliferation and Angiogenic Differentiation in Human Adipose Stem Cells. Aesthetic Surgery Journal 2023; 43(11) doi: 10.1093/asj/sjad139
46
Natalia Trufanova, Oleh Trufanov, Oleksandr Petrenko. Unlocking MSC Potential: Metabolic Reprogramming via Synthetic Biology Approaches. SynBio 2025; 3(3) doi: 10.3390/synbio3030013
47
Luofeng Jiang, Chuting Yu, Heng He, Weishi Kong, Jianyu Lu, Wei Zhang, Jiezhi Lin, Lu Yang, Tianyi Liu, Yongjun Zheng, Zhaofan Xia. Dynamic transcriptomic landscape from bulk RNA-seq reveals critical mmu-miR-181a-5p/hif1a and mmu-miR-101a-3p/col1a1 modules for deep second-degree burn wound healing. Genomics 2026; 118(5) doi: 10.1016/j.ygeno.2026.111304
48
Mehdi Rasouli, Roya Fattahi, Ghader Nuoroozi, Zeinab Zarei-Behjani, Maliheh Yaghoobi, Zeinab Hajmohammadi, Simzar Hosseinzadeh. The role of oxygen tension in cell fate and regenerative medicine: implications of hypoxia/hyperoxia and free radicals. Cell and Tissue Banking 2024; 25(1) doi: 10.1007/s10561-023-10099-9
49
Jiawei Feng, Yichen Yao, Qixue Wang, Xiaozhou Han, Xiaofei Deng, Yemin Cao, Xinghua Chen, Mingmei Zhou, Cheng Zhao. Exosomes: Potential key players towards novel therapeutic options in diabetic wounds. Biomedicine & Pharmacotherapy 2023; 166 doi: 10.1016/j.biopha.2023.115297
50
Gülsemin Çiçek, Fatma Bağcı, Mehmet Filizfidan, Selçuk Duman, Tahsin Aktan. Physicochemical and Biological Modifications in Mesenchymal Stem Cells-Derived Conditioned Media Under Hypoxic Preconditioning: Impact on Oxidative Stress and Nanoparticle Stability. Life 2025; 15(5) doi: 10.3390/life15050702
51
Bogdan-Alexandru Hagiu. Can physical exercise and its mimetics enhance mitochondrial transfusion for Parkinson’s disease therapy?. Medical Hypotheses 2025; 201 doi: 10.1016/j.mehy.2025.111697
52
Yi Liu, Ling Ren, Mengyao Li, Bowen Zheng, Yi Liu. The Effects of Hypoxia-Preconditioned Dental Stem Cell-Derived Secretome on Tissue Regeneration. Tissue Engineering Part B: Reviews 2025; 31(1) doi: 10.1089/ten.teb.2024.0054
53
Marta Camacho-Cardenosa, Victoria Pulido-Escribano, Guadalupe Estrella-Guisado, Gabriel Dorado, Aura D. Herrera-Martínez, María Ángeles Gálvez-Moreno, Antonio Casado-Díaz. Bioprinted Hydrogels as Vehicles for the Application of Extracellular Vesicles in Regenerative Medicine. Gels 2025; 11(3) doi: 10.3390/gels11030191
54
55
Dongdong Ti, Jun Yi, Huihua Chen, Haojie Hao, Chunmeng Shi. The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases. Current Stem Cell Research & Therapy 2024; 19(6) doi: 10.2174/1574888X18666230811093101
56
Özer Aylin Gurpinar, Irmak Dal. Treatment of Induced Mesenchymal Stem Cells in Ischemic Heart Diseases: Hypoxia. Hacettepe Journal of Biology and Chemistry 2025; 53(2) doi: 10.15671/hjbc.1522356
57
Mohamed Sabra, Sharif A. Sabe, Dwight D. Harris, Cynthia M. Xu, Mark Broadwin, Krishnah G. Bellam, Debolina Banerjee, M. Ruhul Abid, Frank W. Sellke. Ischemic myocardial inflammatory signaling in starvation versus hypoxia-derived extracellular vesicles: A comparative analysis. JTCVS Open 2023; 16 doi: 10.1016/j.xjon.2023.10.004
58
Fanyi Zhao, Qixing Tang, Jie Liu. Functional impacts of lactylation in Hypoxia‒primed mesenchymal stromal cells. Frontiers in Cell and Developmental Biology 2025; 13 doi: 10.3389/fcell.2025.1678282
59
Jacob Raiten, Genevieve M. Abd, Shane B. Handelsman, Harshank V. Patel, Jennifer C. Ku, Agata M. Parsons, Jonathan L. Wassink, Sheridan L. Hayes, Juliana Overbay, Yong Li. Hypoxia-induced PD-L1 expression and modulation of muscle stem cell allograft rejection. Frontiers in Pharmacology 2024; 15 doi: 10.3389/fphar.2024.1471563
60
Anne Kari Smedås, Lovise Gangeskar Paris, Niyaz Al‐Sharabi, Einar K. Kristoffersen, Mariano Sanz, Kamal Mustafa, Dagmar Fosså Bunæs, Siddharth Shanbhag. Secretomes of Gingival Fibroblasts From Periodontally Diseased Tissues: A Proteomic Analysis. Clinical and Experimental Dental Research 2025; 11(1) doi: 10.1002/cre2.70103
61
Bárbara Torrecillas-Baena, Victoria Pulido-Escribano, Gabriel Dorado, María Ángeles Gálvez-Moreno, Marta Camacho-Cardenosa, Antonio Casado-Díaz. Clinical Potential of Mesenchymal Stem Cell-Derived Exosomes in Bone Regeneration. Journal of Clinical Medicine 2023; 12(13) doi: 10.3390/jcm12134385
62
Vincent S Gallicchio. Bioregenerative Applications of the Human Mesenchymal Stem Cell- Derived Secretome: Part-I. Journal of Regenerative Medicine & Biology Research 2024;  doi: 10.46889/JRMBR.2024.5202
63
Cathal Patrick Forkan, Aruna Shrestha, Alfred Yu, Christine Chuang, Flemming Pociot, Reza Yarani. Could hypoxic conditioning augment the potential of mesenchymal stromal cell-derived extracellular vesicles as a treatment for type 1 diabetes?. Stem Cell Research & Therapy 2025; 16(1) doi: 10.1186/s13287-025-04153-4
64
Chendong Peng, Jie Yan, Yu’ang Jiang, Lin Wu, Miaoling Li, Xinrong Fan. Exploring Cutting-Edge Approaches to Potentiate Mesenchymal Stem Cell and Exosome Therapy for Myocardial Infarction. Journal of Cardiovascular Translational Research 2024; 17(2) doi: 10.1007/s12265-023-10438-x
65
Dwight D. Harris, Sharif A. Sabe, Mark Broadwin, Cynthia Xu, Christopher Stone, Meghamsh Kanuparthy, Akshay Malhotra, M. Ruhul Abid, Frank W. Sellke. Intramyocardial Injection of Hypoxia-Conditioned Extracellular Vesicles Modulates Response to Oxidative Stress in the Chronically Ischemic Myocardium. Bioengineering 2024; 11(2) doi: 10.3390/bioengineering11020125
66
Luca Bonanni, Nicola Ferri. Mesenchymal Stem Cell-Derived Extracellular Vesicles in Myocardial Ischemia–Reperfusion Injury: A Comprehensive Review. Biology 2026; 15(5) doi: 10.3390/biology15050383
67
María Ángeles de Pedro, Esther López, Francisco Manuel González-Nuño, María Pulido, Verónica Álvarez, Ana María Marchena, Christian Preußer, Witold Szymański, Elke Pogge von Strandmann, Johannes Graumann, Francisco Miguel Sánchez-Margallo, Javier G. Casado, María Gómez-Serrano. Menstrual blood-derived mesenchymal stromal cells: impact of preconditioning on the cargo of extracellular vesicles as potential therapeutics. Stem Cell Research & Therapy 2023; 14(1) doi: 10.1186/s13287-023-03413-5
68
Yi Tian, Xiancheng Wang, Yang Sun, Xiang Xiong, Weiliang Zeng, Kai Yang, Hongli Zhao, Yiwen Deng, Dandan Song. NPTX1 Mediates the Facilitating Effects of Hypoxia-Stimulated Human Adipocytes on Adipose-Derived Stem Cell Activation and Autologous Adipose Graft Survival Rate. Aesthetic Plastic Surgery 2024; 48(20) doi: 10.1007/s00266-024-04118-7
69
Bastien Thauvin, Eric Olmos, Elise Madec, Camille Simon, Julien Branchu, Latifa Chebil. Bead to Bead Transfer, an Efficient Strategy to Scale‐up the Mesenchymal Stromal Cells‐Derived Secretome Bioproduction. Biotechnology and Bioengineering 2025; 122(11) doi: 10.1002/bit.70042
70
M.I. Ezdakova, D.K. Matveeva, I.V. Andrianova, E.R. Andreeva. The sensitivity of multipotent mesenchymal stromal cells to short-term hypoxic stress in vitro depends on the efficiency of homotypic communication through gap junctions. Vestnik Moskovskogo universiteta. Seria 16. Biologia 2023; 78(№3, 2023) doi: 10.55959/MSU0137-0952-16-78-3-7
71
Kevin Audoux, Elise Madec, Julien Branchu, Eric Olmos, Jessica Schiavi-Tritz. Influence of oxygen conditioning on the production of secretome by human mesenchymal stromal cells in stirred bioreactors. Cytotherapy 2026; 28(2) doi: 10.1016/j.jcyt.2025.102003
72
Junyan Zhu, Sicong Wang, Dakai Yang, Wenrong Xu, Hui Qian. Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases. Journal of Nanobiotechnology 2023; 21(1) doi: 10.1186/s12951-023-01921-3
73
74
Dominika Przywara, Wiktor Babiuch, Alicja Petniak, Małgorzata Wasilewska, Jarosław Krzyżanowski, Monika Czuba, Arkadiusz Krzyżanowski, Adrianna Kondracka, Janusz Kocki, Paulina Gil-Kulik. Umbilical Cord Blood Gasometry and pH as Key Regulators of Growth Factor Expression Profile in Umbilical Cord-Derived Mesenchymal Stromal Cells (UC-MSCs). Cells 2026; 15(12) doi: 10.3390/cells15121076
75
Jiantao Wang, Jianxin Cui, Shengqiang Yu, Shujie Xia. Mesenchymal stem cell‐derived extracellular vesicles in treatment against renal fibrosis. Clinical and Translational Discovery 2023; 3(5) doi: 10.1002/ctd2.211
76
Keerthi Nethaji, P. Ashiq Shibili, Amit Dey, Sibin Nambidi, Antara Banerjee, Silvia Barbon, Surajit Pathak, Asim K. Duttaroy. Therapeutic applications of human umbilical cord-derived mesenchymal stem cell secretome in chronic inflammatory diseases and cancer: A recent update. Molecular Immunology 2026; 190 doi: 10.1016/j.molimm.2026.01.006
77
Michael Keese, Jiaxing Zheng, Kaixuan Yan, Karen Bieback, Benito A. Yard, Prama Pallavi, Christoph Reissfelder, Mark Andreas Kluth, Martin Sigl, Vugar Yugublu. Adipose-Derived Mesenchymal Stem Cells Protect Endothelial Cells from Hypoxic Injury by Suppressing Terminal UPR In Vivo and In Vitro. International Journal of Molecular Sciences 2023; 24(24) doi: 10.3390/ijms242417197
78
Zixuan Sun, Jiali Li, Zhijing Wu, Jiaxin Zhang, Tangrong Wang, Yuzhou Zheng, XueZhong Xu, Wei Ding, Hui Qian, Yulin Tan. Extracellular vesicles and their mimetics: clinical application prospects in medical aesthetics. Burns & Trauma 2025; 13 doi: 10.1093/burnst/tkaf033
79
Mefina Kuntjoro, Nike Hendrijantini, Eric Priyo Prasetyo, Bambang Agustono, Guang Hong. Hypoxia-Preconditioned Human Umbilical Cord Mesenchymal Stem Cells Transplantation Ameliorates Inflammation and Bone Regeneration in Peri-Implantitis Rat Model. European Journal of Dentistry 2025; 19(02) doi: 10.1055/s-0044-1791530
80
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