基础研究
Copyright ©The Author(s) 2011.
世界华人消化杂志. 2011-07-08; 19(19): 2011-2015
在线出版 2011-07-08. doi: 10.11569/wcjd.v19.i19.2011
表1 标准曲线数据
取样量(mL)容量瓶体积(mL)芦丁浓度(g/L)吸光度(A)
51000.005900.208
2250.009440.317
5500.011800.415
10500.023600.832
10250.047201.641
表2 不同浓度的水提黄酮类化合物对结肠癌细胞株增殖的抑制率 (mean±SD, %)
浓度(mg/L)24 h
72 h
LoVoSW480HT-29HCT-8LoVoSW480HT-29HCT-8
2.53.15±2.234.48±10.957.90±10.723.79±4.632.50±2.2511.82±10.6313.69±5.461.40±7.15
5.06.78±2.808.36±11.77a14.45±5.1410.13±3.31a9.49±3.8733.27±8.4214.36±3.0519.59±4.50
10.010.84±3.3513.67±6.60a19.27±3.7622.36±1.409.85±1.3637.77±5.8417.04±2.0423.25±3.58
20.013.34±2.6717.53±7.78a21.65±1.3134.62±2.3216.12±1.9352.35±5.7221.82±5.9034.54±5.34
40.017.83±1.63a20.84±7.80a22.23±2.1337.51±0.58a34.51±5.2668.17±7.7625.02±15.4254.51±5.15
60.024.34±2.54a32.79±4.69a24.20±2.41a49.75±4.8956.37±2.3171.08±8.1649.15±5.6457.02±6.76
80.030.37±2.05a41.69±0.89a32.25±3.70a52.50±3.39a66.43±2.7676.00±5.8756.25±2.0969.87±3.52
表3 不同浓度的醇提黄酮类化合物对结肠癌细胞株增殖的抑制率 (mean±SD, %)
浓度(mg/L)24 h
72 h
LoVoSW480HT-29HCT-8LoVoSW480HT-29HCT-8
2.52.40±0.953.90±1.69a2.67±2.652.84±2.3112.59±7.039.41±2.884.05±6.9110.09±5.31
5.05.56±1.21a8.24±2.976.78±0.6710.22±7.4917.66±2.8013.28±11.966.24±13.5113.02±6.02
10.06.97±0.79a12.03±4.678.44±1.8221.40±1.2720.36±3.5417.36±5.248.28±9.0122.66±8.12
20.08.71±1.15a14.71±3.8214.90±10.2727.42±5.9921.52±4.6024.15±5.5410.64±10.8826.52±7.74
40.011.87±0.93a18.02±4.14a16.37±5.5929.68±5.9525.49±3.4732.79±6.0236.57±12.8538.37±1.70
60.017.00±2.06a21.94±4.81a24.25±11.2930.30±4.17a39.53±2.1847.55±2.4542.63±14.2244.82±5.99
80.022.34±2.61a29.91±3.43a27.72±13.8633.59±2.39a53.90±1.8160.35±6.6150.04±8.8947.37±2.71
表4 洋葱提取物对不同细胞的IC50 (mg/L)
细胞24 h
72 h
乙醇乙醇
LoVo426.1201 246.50455.106141.085
SW480193.312618.63317.00571.438
HT-2994.883463.34617.00584.062
HCT-862.612223.16335.82392.338
表5 24 h相同浓度下水提物与醇提物对结肠癌细胞株增殖的抑制作用 (mean±SD, %)
浓度(mg/L)水提物
醇提物
LoVoSW480HT-29HCT-8LoVoSW480HT-29HCT-8
2.53.15±2.234.48±10.957.90±10.723.79±4.632.40±0.953.90±1.692.67±2.652.84±2.31
5.06.78±2.808.36±11.7714.45±5.1410.13±3.315.56±1.218.24±2.976.78±0.6710.22±7.49
10.010.84±3.3513.67±6.6019.27±3.76a22.36±1.406.97±0.7912.03±4.678.44±1.8221.40±1.27d
20.013.34±2.6717.53±7.7821.65±1.3134.62±2.32d8.71±1.1514.71±3.8214.90±10.2727.42±5.99
40.017.83±1.63a20.84±7.8022.23±2.1337.51±0.58d11.87±0.9318.02±4.1416.37±5.5929.68±5.95d
60.024.34±2.54a32.79±4.69a24.20±2.4149.75±4.89ad17.00±2.0621.94±4.8124.25±11.2930.30±4.17
80.030.37±2.05a41.69±0.89a32.25±3.7052.50±3.39ad22.34±2.6129.91±3.4327.72±13.8633.59±2.39
表6 72 h相同浓度下水提物与醇提物对结肠癌细胞株增殖的抑制作用 (mean±SD, %)
浓度(mg/L)24 h
72 h
LoVoSW480HT-29HCT-8LoVoSW480HT-29HCT-8
2.52.50±2.2511.82±10.6313.69±5.461.40±7.1512.59±7.039.41±2.884.05±6.9110.09±5.31
5.09.49±3.87a33.27±8.4214.36±3.0519.59±4.5017.66±2.8013.28±11.966.24±13.5113.02±6.02
10.09.85±1.36a37.77±5.84ad17.04±2.0423.25±3.5820.36±3.5417.36±5.248.28±9.0122.66±8.12
20.016.12±1.9352.35±5.72ad21.82±5.9034.54±5.3421.52±4.6024.15±5.5410.64±10.8826.52±7.74
40.034.51±5.2668.17±7.76a25.02±15.4254.51±5.15a25.49±3.4732.79±6.0236.57±12.8538.37±1.70
60.056.37±2.31a71.08±8.16a49.15±5.6457.02±6.7639.53±2.1847.55±2.4542.63±14.2244.82±5.99
80.066.43±2.76a76.00±5.87a56.25±2.0969.87±3.52a53.90±1.8160.35±6.6150.04±8.8947.37±2.71

引文著录: 周阿成, 金黑鹰, 谈瑄忠, 钱晓磊, 张春霞, 何勇山, 王水明. 洋葱提取物对结肠癌细胞增殖的抑制作用. 世界华人消化杂志 2011; 19(19): 2011-2015