肝癌基因谱动态表达及HSPgp96异常的临床价值

表1 肝细胞癌变过程中大鼠全基因表达谱比较与分析

分组	基因上调(SR值)		基因下调(SR值)
	≥8	≥2	≥8	≥2
胎肝与癌前组	292	1149	318	1546
胎肝与癌变组	559	1821	425	2072
胎肝与正常组	483	1439	234	1464
癌前与癌变组	132	1269	116	629
癌前组与正常	268	1179	57	767
癌变组与正常	312	1371	201	1355

表2 与正常组比较, 癌变组明显上调的基因

Accession numbers	protein	SLR( = log2cy5/cy3)
BI274917	Laminin, alpha5	5.9
NM031511	insulin-like growth factor 2	3.8
NM012912	activating transcription factor 3, ATF3	3.6
BG376410	tumor-associated calcium signal transducer 1	3.6
BI289940	hepatoma-derived growth factor related protein3, HDGFRP3	3.2
BG057543	tumor rejection gp96	3
AA963751	tumor necrosis factor receptor superfamily, member17	2.7
BM384099	N-myc downstream regulated gene1	2.2
BG375362	latent transforming growth factor beta binding protein4	2
NM012967	intercellular adhesion molecule1	2
NM013043	transforming growth factor beta1 induced transcript 4	1.7
BE099050	nuclear factor L/B	1.5
NM012493	alpha-fetoprotein	1.4