大鼠胚胎胰腺外分泌功能基因的表达调控

表1 E15.5-E18.5胰腺外分泌功能相关基因差异表达谱

探针号	GenBank号	相关功能	差异(18.5/15.5)
1369787_at	NM_012688	Cholecystokinin A receptor (Cckar)	14.93↑P/A
1387700_at
1368005_at	NM_013138	Inositol 1, 4, 5-triphosphate receptor 3 (IP3R3)	1.52↑P/P
1368316_at	NM_019158	Aquaporin 8	45.25↑P/A
1371160_at	AJ133104	Vesicle-associated membrane protein 2 (VAMP-2)	A/A
1387819_at	NM_012552	Elastase 1	4.59↑P/P
1387471_at	NM_012553	Elastase 2(Ela2)	22.63↑P/A
1369951_at	NM_012536	Chymotrypsin B (Ctrb1)	21.11↑P/P
1369030_at	NM_012635	Pancreatic trypsin 1	4.29↑P/P
1370126_at	NM_012729	Pancreatic trypsin II (Prss2)	68.59↑P/A
1368532_at	NM_032081	Pancreatic lipase related protein 1	5.28↑P/P
1369701_at	NM_012597	Lipase (Lipc)	2.64↑P/P
1370084_at	NM_012533	Carboxypeptidase B (Cpb)	4.29↑P/A
1369657_at	NM_016998	Carboxypeptidase A1 (Cpa1)	1.87↑P/P
1387503_at	NM_053526	Carboxypeptidase N (Cpn1)	2.64↑P/P
1369206_at	NM_05361	Carboxypeptidase B2 (plasma) (Cpb2)	3.73↑P/A
1368196_at	NM_013139	Colipase pancreatic (Clps)	21.11↑P/P
1370831_at	AY081195	Monoglyceride lipase	3.48↑P/A
1369502_a_at	NM_031502	Amylase 1	2.14↑P/P

↑: 从E15.5到E18.5表达上升, ↓: 从E15.5到E18.5表达下降, P: 有表达, A: 无表达.

表2 E15.5-E18.5胰腺发育相关转录因子及相关信号分子差异表达谱

	探针号	GeneBank号	名称及相关功能	差异倍数(18.5/15.5)
bHLH	1387212_at	NM_012863	Muscle, intestine and stomachexpression 1(mist1)	7.46↑P/p
	1369803_at	NM_053964	Pancreas specific transcriptionfactor, 1a (Ptf1a) or Ptf1-P48	5.28↑P/p
ZF domain	1387894_at	L22761	GATA binding protein 4 (Gata4)	2↑P/p
	1368510_at	NM_012764	GATA binding protein 1(Gata1)	3.48↑P/p
	1368827_at	NM_019185.1	GATA-binding protein 6 (Gata6)	2.14↑P/p
HD	1369681_at	NM_017339	ISL1 transcription factor,LIM / homeodomain 1(Isl1)	2.64↑P/A
	1369516_at	NM_022852	Pancreatic and duodenal homeobox gene 1 (Pdx1)	1.74↑P/A
	1368873_at	NM_012581	Hoxa2	2.30↑P/p
	1388197_at	AA900970	Hoxa4	3.48↑P/A
	1370969_at	BE107303	Hoxa5	3.48↑P/P
Others	1371034_at	NM_022671	Hepatocyte nuclear factor 6	1.87↑P/p
	1368998_at	NM_031737	NK homeobox (Drosophila),family 6, A (NKX6.1)	2.14↓P/p

↑: 从E15.5到E18.5表达上升, ↓: 从E15.5到E18.5表达下降, P: 有表达, A: 无表达.