丝裂霉素联合舒林酸对胃癌SGC7901细胞诱导凋亡的研究

表1 药物对SGC7901细胞凋亡及细胞周期的影响(%, mean±SD)

Group	Apoptosis	G0 /G1	S	G2/M
Control	0.43±0.38	47.43±2.81	45.50±1.25	7.06±4.06
Sulindac	3.80±0.53a	49.67±3.29	44.70±5.82	4.97±6.52
MMC	7.20±1.31a	56.67±3.92a	40.40±11.53	6.60±2.99
Combined	11.97±2.59b	68.40±5.53b	29.23±5.87	2.37±0.45

^aP<0.05 vs Control;

^bP<0.01 vs MMC.

表2 药物干预24 h对SGC7901细胞COX-2及Bcl-2蛋白表达的影响 (mean±SD, n = 3, A)

Group	COX-2	Bcl-2
Control	0.4 980±0.0 330	0.3 652±0.057
Sulindac	0.3 967±0.0 306a	0.2 617±0.0 333b
MMC	0.5 633±0.0 208	0.4 500±0.0 436b
Combined	0.4 000±0.0 265ac	0.3 660±0.0 397c

^aP<0.01,

^bP<0.05 vs control;

^cP<0.05 vs MMC.