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©The Author(s) 2003.
世界华人消化杂志. 2003-09-15; 11(9): 1349-1352
在线出版 2003-09-15. doi: 10.11569/wcjd.v11.i9.1349
在线出版 2003-09-15. doi: 10.11569/wcjd.v11.i9.1349
表1 肝癌组(1-5)与非肝癌组(6-17) X基因序列同源性比较
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | |
| 1 | 92.9 | 97.8 | 92.9 | 91.7 | 95.7 | 90.4 | 90.9 | 90.7 | 91.1 | 97.6 | 90.0 | 88.4 | 91.3 | 91.1 | 90.7 | 91.3 | |
| 2 | 91.7 | 97.8 | 96.1 | 90.4 | 94.7 | 97.0 | 96.7 | 96.7 | 90.7 | 95.5 | 94.1 | 97.0 | 96.7 | 96.1 | 95.7 | ||
| 3 | 91.7 | 91.5 | 95.7 | 90.2 | 90.7 | 90.4 | 90.9 | 95.9 | 89.8 | 88.2 | 90.9 | 91.1 | 90.4 | 91.1 | |||
| 4 | 97.0 | 89.4 | 95.3 | 96.7 | 96.1 | 96.1 | 90.4 | 94.9 | 93.7 | 96.3 | 96.1 | 95.7 | 96.5 | ||||
| 5 | 90.5 | 97.4 | 98.1 | 97.9 | 97.9 | 91.7 | 97.1 | 93.1 | 98.3 | 97.9 | 97.8 | 98.4 | |||||
| 6 | 90.0 | 90.8 | 91.3 | 91.7 | 97.9 | 90.7 | 86.9 | 91.7 | 91.3 | 91.0 | 90.8 | ||||||
| 7 | 97.2 | 97.6 | 97.4 | 91.0 | 96.9 | 93.3 | 97.8 | 97.8 | 97.1 | 97.9 | |||||||
| 8 | 98.8 | 98.8 | 90.8 | 97.9 | 94.1 | 99.1 | 98.8 | 98.6 | 98.3 | ||||||||
| 9 | 99.3 | 91.3 | 98.1 | 94.1 | 99.3 | 99.0 | 98.6 | 98.4 | |||||||||
| 10 | 91.7 | 98.1 | 94.1 | 99.3 | 99.0 | 98.8 | 98.4 | ||||||||||
| 11 | 90.7 | 86.9 | 91.7 | 91.3 | 91.2 | 91.9 | |||||||||||
| 12 | 94.1 | 98.4 | 98.4 | 97.9 | 97.6 | ||||||||||||
| 13 | 94.5 | 94.5 | 93.9 | 93.6 | |||||||||||||
| 14 | 99.3 | 99.1 | 98.8 | ||||||||||||||
| 15 | 98.8 | 98.4 | |||||||||||||||
| 16 | 98.6 |
表2 HBV X区核苷酸热点变异
| 碱基变异位点 | 肝癌组 | 非肝癌组 | 合计 |
| nt 1 361 G→A | 4 | 2 | 6 |
| nt 1 466 C→T | 3 | 2 | 5 |
| nt 1 490 C→T | 3 | 2 | 5 |
| nt 1 510 A→T | 3 | 2 | 5 |
| nt 1 640 C→T | 3 | 2 | 5 |
| nt 1 644 G→A | 3 | 2 | 5 |
| nt 1 764 A→T | 4 | 3 | 7 |
| nt 1 766 G→A | 4 | 3 | 7 |
| nt 1 859 A→T | 5 | 2 | 7 |
引文著录: 代志琰, 徐启桓, 李刚, 马会慧, 汤正好, 舒欣, 姚集鲁. 肝癌患者乙型肝炎病毒X基因变异的研究. 世界华人消化杂志 2003; 11(9): 1349-1352