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HGF gene modified bone marrow mesenchymal stem cells for treatment of hepatic fibrosis
Qi-Yuan Zou, Xiao-Dan Lv, Lan Chen, Ling-Ling Zhan, Xiao-Ping Lv
Qi-Yuan Zou, Lan Chen, Xiao-Ping Lv, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Xiao-Dan Lv, Ling-Ling Zhan, Department of Clinical Experimental Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Supported by: National Natural Science Foundation of China, No. 81460114; the Natural Science Foundation of Guangxi Zhuang Autonomous Region, No. 2012GXNSFAA053143; the Scientific Research and Technology Development Project of Guangxi, No. 1355005-3-2.
Correspondence to: Xiao-Ping Lv, Professor, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. lxxp58@hotmail.com
Received: October 1, 2015 Revised: October 22, 2015 Accepted: November 3, 2015 Published online: December 8, 2015
Hepatic fibrosis is a reversible pathological change caused by liver cell inflammation, necrosis, or abnormal hyperplasia of connective tissue. It has been proved that hepatocyte growth factor (HGF) gene modified bone marrow mesenchymal stem cells can reduce or inhibit liver fibrosis, with better effects than those of unmodified bone marrow mesenchymal stem cells. Thus, HGF gene modified bone marrow mesenchymal stem cells represent a promising method for anti-hepatic fibrosis.
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