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Regulation of mucosal immunity and preventing infectious disease occurrence by intestinal microbiota
Jian-Yun Yuan, Yan-Hong Zhou
Jian-Yun Yuan, Suizhou Hospital of Hubei University of Medicine; Outpatient Department of Internal Medicine of Jiliang District, Central Hospital of Suizhou City, Suizhou 441300, Hubei Province, China
Yan-Hong Zhou, Clinical Medical College, Hubei University of Science and Technology, Xianning 437100, Hubei Province, China
Supported by: Fund Project of Hubei Provincial Health and Family Planning Commission, No. WJ2015MB236.
Correspondence to: Yan-Hong Zhou, Professor, Clinical Medical College, Hubei University of Science and Technology, 88 Xianning Road, Xianning 437100, Hubei Province, China. yanhongzhou326@163.com
Received: August 30, 2015 Revised: September 16, 2015 Accepted: September 28, 2015 Published online: October 28, 2015
Trillions of bacteria are colonizing in the mammalian intestine, and most of these bacteria have co-evolved with the host in a symbiotic relationship. A principal function of the intestinal microbiota is to regulate the gut immune response and protect the intestine against pathogen infection. In this review, we provide an overview of the current understanding of the role of intestinal microbiota both in the development of intestinal lymphoid tissue and immune cells, and in directly or indirectly preventing the occurrence of infectious diseases.
Key Words: Microbiota; Lymphoid development; Immune cells; Resistance to pathogens
Citation: Yuan JY, Zhou YH. Regulation of mucosal immunity and preventing infectious disease occurrence by intestinal microbiota. Shijie Huaren Xiaohua Zazhi 2015; 23(30): 4852-4858
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