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方法: 全面检索Pubmed、Excerpta Medica Database (Embase)、Chinese Biomedical Literature Database (CBM)and the Cochrane Library、维普、万方数据库, 收集研究miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性相关性的文献. 对miRNA-146a rs2910164 G/C各基因型的比较模型(G vs C、 GG vs CC、GG vs GC、GC vs CC、GG + GC vs CC、GG vs GC + CC)进行定量综合分析.
结果: 共纳入7篇文献, 共有大肠癌患者2978例, 健康对照3576例. Meta分析尚未发现miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性具有相关性(G vs C: OR = 0.82, 95%CI: 0.52-1.30, P = 0.41; GG vs CC:OR = 1.10, 95%CI: 0.72-1.40, P = 0.97; GG vs GC: OR = 1.10, 95%CI: 0.81-1.28, P = 0.91; GC vs CC: OR = 0.99, 95%CI: 0.70-1.41, P = 0.96; GG + GC vs CC: OR = 1.00, 95%CI: 0.72-1.39, P = 0.99; GG vs GC + CC: OR = 1.00, 95%CI: 0.81-1.24, P = 0.98).
Association between miRNA-146a rs2910164 gene polymorphism and susceptibility to colorectal cancer: A systematic review
Wen-Qun Xie, Shi-Yun Tan, Xiao-Fan Wang
Wen-Qun Xie, Shi-Yun Tan, Xiao-Fan Wang, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Correspondence to: Shi-Yun Tan, Chief Physician, Department of Gastroenterology, Renmin Hospital of Wuhan University, 99 Wuchang Ziyang Road, Wuhan 430060, Hubei Province, China. tanshiyun@medmail.com.cn
Received: December 8, 2013 Revised: January 2, 2014 Accepted: January 8, 2014 Published online: February 28, 2014
AIM: To accurately evaluate the association between the miRNA-146a rs2910164G/C polymorphism and susceptibility to colorectal cancer.
METHODS: An electronic search of PubMed, Excerpta Medica Database (Embase), Chinese Biomedical Literature Database (CBM), the Cochrane Library, Weipu and Wanfang Database was performed to collect all the publications investigating the association between miR-146a rs2910164G/C polymorphism and risk of colorectal cancer. We then analyzed the differences in miRNA-146a rs2910164G/C genotypes (G vs C, GG vs CC, GG vs GC, GC vs CC, GG + GC vs CC, GG vs GC + CC) between cases and controls by meta-analysis.
RESULTS: Seven studies involving 2978 cases and 3576 controls were found to be eligible for meta-analysis. We summarized the data on the association between miR-146a rs2910164G/C polymorphism and risk of colorectal cancer in the overall population. In the overall analysis, there was no evidence for an association between the miR-146a rs2910164 polymorphism and the risk of colorectal cancer (G vs C: OR = 0.82, 95%CI: 0.52-1.30, P = 0.41; GG vs CC: OR = 1.10, 95%CI: 0.72-1.40, P = 0.97; GG vs GC: OR = 1.10, 95%CI: 0.81-1.28, P = 0.91; GC vs CC: OR = 0.99, 95%CI: 0, 70-1.41, P = 0.96; GG + GC vs CC: OR = 1.00, 95%CI: 0.72-1.39, P = 0.99; GG vs GC + CC: OR = 1.00, 95%CI: 0.81-1.24, P = 0.98).
CONCLUSION: This meta-analysis demonstrated that the miR-146a rs2910164 polymorphism is not associated with colorectal cancer susceptibility.
Key Words: MicroRNA; Single nucleotide polymorphisms; Colorectal cancer; Meta-analysis
Citation: Xie WQ, Tan SY, Wang XF. Association between miRNA-146a rs2910164 gene polymorphism and susceptibility to colorectal cancer: A systematic review. Shijie Huaren Xiaohua Zazhi 2014; 22(6): 890-897
对纳入研究进行Meta分析, 因纳入研究的各基因型均存在显著的异质性(I2>50%), 故采用随机效应模型进行数据合并. 各基因型合并OR及其95%CI结果如表2所示: G vs C: OR = 0.82, 95%CI: 0.52-1.30, P = 0.41; GG vs CC: OR = 1.10, 95%CI: 0.72-1.40, P = 0.97; GG vs GC: OR = 1.10, 95%CI: 0.81-1.28, P = 0.91; GC vs CC: OR = 0.99, 95%CI: 0.70-1.41, P = 0.96; GG + GC vs CC: OR = 1.00, 95%CI: 0.72-1.39, P = 0.99; GG vs GC + CC: OR = 1.00, 95%CI: 0.81-1.24, P = 0.98. 分析结果发现, miR-146a rs2910164 G/C基因多态性与大肠癌易感性之间无关联. 为评估纳入文献的发表偏倚, 做了Begg's漏斗图及Egger's线性回归分析(表3, 图2), miR-146a rs2910164 G/C各基因模型的Egger's线性回归分析结果为P值均>0.05, 表明不存在发表偏倚.
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