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P38 MAPK signaling pathway: biological functions, roles in the pathogenesis of liver fibrosis and common research methods
Ping Ye, Bo Yang, Xiao-Ling Wu, Ming-De Jiang
Ping Ye, Bo Yang, Xiao-Ling Wu, Ming-De Jiang, Department of Gastroenterology, General Hospital of Chengdu Military Command of Chinese PLA, Chengdu 610083, Sichuan Province, China
Correspondence to: Ming-De Jiang, Professor, Department of Gastroenterology, General Hospital of Chengdu Military Command of Chinese PLA, Chengdu 610083, Sichuan Province, China. jiangmd88@yahoo.com.cn
Received: September 19, 2011 Revised: October 20, 2011 Accepted: November 9, 2011 Published online: November 18, 2011
The activation and proliferation of hepatic stellate cells (HSC) are the key events in hepatic fibrogenesis. Now the research about the mechanisms of action of HSC-related signal transduction has become a hot topic. This article reviews the biological functions of the p38 MAPK signaling pathway and its roles in the pathogenesis of liver fibrosis and summarizes common research methods for this signaling pathway.
Key Words: P38 MAPK; Function; Research method; Liver fibrosis; Mechanism
Citation: Ye P, Yang B, Wu XL, Jiang MD. P38 MAPK signaling pathway: biological functions, roles in the pathogenesis of liver fibrosis and common research methods. Shijie Huaren Xiaohua Zazhi 2011; 19(32): 3353-3358
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