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Wen-Po Feng, Li-Xiang Chen, Xiao-Dan Kou, Jing-Jing Xu, Qiao-Zhen Kang, Yuan-Ming Qi, Department of Bioengineering, Zhengzhou University, Zhengzhou 450001, He'nan Province, China
Supported by: the Medical Science and Technique Innovation Talent Project of He'nan Province, No. 200311201 and the Tackle Key Problems in Science and Technology Project of He'nan Province, No. 0495060801.
Correspondence to: Yuan-Ming Qi, Department of Bioengineering, Zhengzhou University, 100 Science Road, Zhengzhou 450001, He'nan Province, China. qym@zzu.edu.cn
Received: February 5, 2007 Revised: July 16, 2007 Accepted: July 28, 2007 Published online: August 8, 2007
AIM: To investigate the expression of protein 4.1 family members (4.1R, 4.1N, 4.1G, 4.1B) and to determine the pathological features of colorectal carcinoma.
METHODS: The expression of 4.1 proteins was detected with an envision immunohistochemical assay in 94 paraffin-embedded samples from patients with colorectal carcinoma. Correlations between proteins 4.1R, N, G and B and colorectal carcinoma were analyzed.
RESULTS: Expression of 4.1s in colorectal carcinoma tissues was clearly lower compared with that in normal tissue (Hc = 44.70, Hc = 31.41, Hc = 13.62; all P < 0.01), except for 4.1G. Expression of 4.1N and B in colorectal carcinoma tissues was positively correlated with cell differentiation (rs = 0.27, rs = 0.28; both P < 0.01). The expression of 4.1R was associated with the degree of soakage (rs = 0.03, P < 0.01) and lymphatic metastasis (rs = 0.24, P < 0.05); further, the expression of 4.1G was up-regulated with soakage (rs = 0.24, P < 0.05). There was no significant relationship between expression of 4.1s in colorectal carcinoma tissue and patient age or gender.
CONCLUSION: The expression of 4.1s may participate in the occurrence and progression of colorectal carcinoma. Expression of 4.1N and 4.1B are closely related with histological grade, and proteins 4.1R and 4.1G are associated with soakage of colorectal carcinoma.
Key Words: Protein 4.1; Colorectal carcinoma; Immunohistochemistry
Citation: Feng WP, Chen LX, Kou XD, Xu JJ, Kang QZ, Qi YM. Expression of genes for human membrane skeleton protein 4.1s in colorectal carcinoma. Shijie Huaren Xiaohua Zazhi 2007; 15(22): 2436-2441
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