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Ai-Guang Zhao, Jin-Kun Yang, Jian Zheng, Ke-Ping Shen, Department of Oncology Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Yong Cai, School of Public Health, the Second Medical University of Shanghai, Shanghai 200025, China
Supported by Shanghai Science and Technique Ministerial Foundation, No. 02QB14043; and Shanghai High-Education Bureau Foundation, No. 01C06.
Correspondence to: Dr. Ai-Guang Zhao, Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Shanghai 200032, China. firstname.lastname@example.org
Received: January 21, 2005 Revised: February 1, 2005 Accepted: February 16, 2005 Published online: May 1, 2005
AIM: To evaluate the effect of Chinese jianpi herbal recipe Wei Chang An (WCA) on the prognosis of gastric cancer.
METHODS: Univariate and Cox regressions were applied to analyze the influence of the clinical, pathological and therapeutical variables on the prognosis of 166 gastric cancer patients.
RESULTS: In univariate analysis, the significant prognostic factors were the site of the tumor, the TNM stage, surgery, chemotherapy and WCA. Multivariate analysis suggested that the TNM stage, radical resection, and WCA were independent prognostic factors. Patients who received WCA demonstrated better prognosis independent of other prognostic factors in multivariate analysis. The odds ratios [Exp(B)] of stage II, III and IV were 0.091 (95%CI: 0.028-0.294), 0.038 (95%CI: 0.008-0.175) and 0.303 (95%CI: 0.152-0.603), respectively. Exp(B) of WCA was 3.575 (95%CI: 1.768-7.228). The site of the tumor and chemotherapy had no influence on survival in multivariate analysis (P>0.05).
CONCLUSION: Cox regression analysis is a proper statistical method for the evaluation of the effectiveness of Traditional Chinese Medicine therapy on gastric cancer. The Chinese jianpi herbal recipe WCA has important value for improving the prognosis of gastric cancer.
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