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Association between HLA classⅡgenes and severity of chronic hepatitis B
Ye-Gui Jiang, Yu-Ming Wang
Ye-Gui Jiang, Yu-Ming Wang, Institute of Infectious Diseases. Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Correspondence to: Ye-Gui Jiang, Institute of Infectious Diseases. Southwest Hospital, Third Military Medical University, Chongqing 400038, China. jiangyegui@yahoo.com.cn
Received: March 8, 2003 Revised: March 25, 2003 Accepted: April 5, 2003 Published online: March 15, 2004
AIM: To investigate the association between the polymorphism of HLA -DRB1, -DQA1 and -DQB1 alleles and severity of chronic hepatitis B.
METHODS: HLA-DRB1, -DQA1 and -DQB1 alleles in 54 patients with chronic hepatitis B and 32 patients with chronic severe hepatitis B were analyzed by using polymerase chain reaction/sequence specific primer (PCR/SSP) technique.
RESULTS: The frequency of HLA-DRB1*1 001 allele in the chronic severe hepatitis B group was markedly higher than that in the chronic hepatitis B group (14.1% vs 1.9%, x2 = 19.2997, Pc = 0.0281, RR = 9.78). No significant different allele frequencies of HLA-DQA1 and HLA-DQB1 alleles were observed between the chronic severe hepatitis B group and the chronic hepatitis B group.
CONCLUSION: HLA-DRB1*1 001 is closely associated with the severity of chronic hepatitis B, and may be a valuble marker of evaluating the prognosis of patients with chronic hepatitis B.
Key Words: N/A
Citation: Jiang YG, Wang YM. Association between HLA classⅡgenes and severity of chronic hepatitis B. Shijie Huaren Xiaohua Zazhi 2004; 12(3): 622-625
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