EGCG对氟尿嘧啶抑制肝癌细胞生长的增强作用

图1 EGCG下调BEL-7402细胞COX-2蛋白的表达. 1: 对照组; 2: 10 μmol/L 5-FU; 3: 10 μmol/L EGCG; 4: 25 μmol/L EGCG; 5: 50 μmol/L EGCG; 6: 5-FU+25 μmol/L EGCG.

图2 COX-2表达下调参与联合用药的协同作用. A: Western blot显示COX-2蛋白被敲出; B: BEL-7402细胞经各处理因素处理后的生存率. 1: 对照组; 2: 5-FU; 3: EGCG; 4: EGCG+5-FU; 5: Cont siRNA; 6: COX-2 siRNA; 7: 5-FU+Cont siRNA; 8: 5-FU+COX-2 siRNA. ^aP<0.05 vs 对照组.