Effect of enterokinetic prucalopride on intestinal motility in fast rats

Table 1 One h effect of prucalopride on intestinal motility in SD rats (^-x±s, n = 10)

Group	GI length (cm)	Migration of activated charcoal (cm)	GI propulsion rate (%)
Control	82.9 ± 12.2	63.8 ± 10.5	77.9 ± 7.5
Prucalopride (1 mg/kg)	70.9 ± 4.1	59.7 ± 9.5	84.0 ± 11.7b
Prucalopride (2 mg/kg)	73.8 ± 11.7	57.0 ± 12.8	77.1 ± 11.9a
Cisapride (1 mg/kg)	78.1 ± 10.7	52.2 ± 14.4	66.3 ± 13.6

^aP < 0.05,

^bP < 0.01, vs cisapride.

Table 2 Two h effect of prucalopride on intestinal motility in SD rats (^-x±s, n = 10)

Group	GI length (cm)	Migration of activated charcoal (cm)	GI propulsion rate (%)
Control	91.9 ± 11.8	63.9 ± 3.8	70.5 ± 9.2
Prucalopride (1 mg/kg)	87.1 ± 8.5	72.6 ± 10.0	83.2 ± 5.5bd
Prucalopride (2 mg/kg)	100.1 ± 12.2	81.9 ± 14.0	81.7 ± 8.5ad
Cisapride (1 mg/kg)	95.4 ± 12.3	72.0 ± 6.9	75.4 ± 5.9

^aP < 0.05,

^bP < 0.01, vs cisapride;

^dP < 0.01, vs control.

Table 3 Four h effect of prucalopride on intestinal motility in SD rats (^-x±s, n = 10)

Group	GI length (cm)	Migration of activated charcoal (cm)	GI propulsion rate (%)
Control	89.9 ± 8.6	78.0 ± 7.3	86.8 ± 2.6
Prucalopride (1 mg/kg)	83.7 ± 5.1	76.3 ± 5.2	91.2 ± 2.2ad
Prucalopride (2 mg/kg)	97.4 ± 9.8	87.3 ± 10.4	91.3 ± 3.9ad
Cisapride (1 mg/kg)	99.5 ± 12.7	88.1 ± 13.7	88.6 ± 3.5

^aP < 0.05, vs cisapride;

^dP < 0.01, vs control.