Construction and expression of a humanized M2 autoantigen trimer and its application in the diagnosis of primary biliary cirrhosis

Table 1 AMA and M₂ antibodies in patients with different diseases

Group	n	AMA positive	M2 - positive		AASLD's guideline (+)
			Euroimmun's kit	ELISA
PBC	20	20	16	20	20
AIH	5	0	0	1	0
AIC	2	0	1	2	0
LDUE	18	7	6	6	6
DILI	8	1	1	1	1
Other liver diseases	201	ND	ND	0	ND
AID	33	3	0	0	0
Control	1225	ND	ND	0	ND

PBC: primary biliary cirrhosis; AIH: autoimmune hepatitis; AIC: autoimmune cholangitis; LDUE: liver disease with unknown etiology; DILI: drug induced liver injury; AID: autoimmune disease; AMA: antimitochondrial antibodies; ND: not done.