Tumor necrosis factor-related apoptosis-inducing ligand gene on human colorectal cancer cell line HT29

doi:10.3748/wjg.v9.i5.965

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May 15, 2003 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. May 15, 2003; 9(5): 965-969
Published online May 15, 2003. doi: 10.3748/wjg.v9.i5.965

Table 1 Cell growth inhibition of recombinant adenovirus on HT29 cell

Group	OD (^-x±s)	Cell growth inhibition rates (%)
Ad/GT-TRAIL	0.57 ± 0.12^a^c	52.5
Ad/GT-Bax	0.84 ± 0.08^a	30.3
Ad/GT-LacZ	1.07 ± 0.13	10.5
PBS	1.20 ± 0.17	0.0

^aP < 0.05, vs LacZ, PBS groups;

^cP < 0.05, vs Bax group.

Table 2 Cell growth inhibition of recombinant adenovirus on HT29 cell when combined with Ad/PGK-GV16

Group	OD (^-x±s)	Cell growth inhibition rates (%)
Ad/GT-TRAIL + Ad/PGK-GV16	0.18 ± 0.03^a^c	85.2
Ad/GT-Bax + Ad/PGK-GV16	0.46 ± 0.09^a	61.5
Ad/GT-LacZ + Ad/PGK-GV16	1.05 ± 0.07	12.1
PBS	1.20 ± 0.17	0.0

^aP < 0.05, vs LacZ, PBS groups;

^cP < 0.01, vs Bax group.

Table 3 The percentage of apoptotic cells of recombinant adenovirus on HT29 cell after 5 d treatment

Group	The percentage of apoptotic cells (%, ^-x±s)
Ad/GT-TRAIL	16.50 ± 1.13^a
Ad/GT-Bax	14.70 ± 0.46^a
Ad/GT-LacZ	7.45 ± 0.75
PBS	6.15 ± 0.23

^aP < 0.05, compared with LacZ, PBS groups.

Table 4 The percentage of apoptotic cells of recombinant adenovirus on HT29 cell when combined with Ad/PGK-GV16 after 5 d treatment

Group	The percentage of apoptotic cells (%, ^-x±s)
Ad/GT-TRAIL + Ad/PGK-GV16	35.90 ± 1.32^a
Ad/GT-Bax + Ad/PGK-GV16	29.00 ± 1.66^a
Ad/GT-LacZ + Ad/PGK-GV16	11.23 ± 1.14
PBS	6.15 ± 0.23

^aP < 0.01, compared with LacZ, PBS groups.

Citation: Xu XM, He C, Hu XT, Fang BL. Tumor necrosis factor-related apoptosis-inducing ligand gene on human colorectal cancer cell line HT29. World J Gastroenterol 2003; 9(5): 965-969
URL: https://www.wjgnet.com/1007-9327/full/v9/i5/965.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i5.965