Gastroesophageal manometry and 24-hour double pH monitoring in neonates with birth asphyxia

Table 1 Esophageal and gastric pressure in asphyxia infants (mean ± SD, kPa)

Groups	n	Gastric pressure	LESP	LESP-gastric pressure	Esophageal pressure	UESP
Asphyxia	35	0.89 ± 0.07	3.22 ± 0.14	2.33 ± 0.13	-0.33 ± 0.05	2.38 ± 0.13
Mild	28	0.99 ± 0.06	3.32 ± 0.15	2.31 ± 0.14	-0.34 ± 0.05	2.34 ± 0.15
Severe	7	0.49 ± 0.20b	2.90 ± 0.33	2.42 ± 0.36	-0.30 ± 0.09	2.55 ± 0.31
Control	17	0.86 ± 0.07	3.37 ± 0.29	2.47 ± 0.29	-0.38 ± 0.06	2.45 ± 0.22

^bP < 0.01, vs mild asphyxia group.

Table 2 24-h esophageal pH monitoring in asphyxia (mean ± SD)

Groups	n	Acid reflux index	Reflux episodes	Episode > 5 min	Duration of longest episode pH < 4	Total time pH < 4	Area under pH < 4 curve	Esoph. clear time
Asphyxia	35	7.1 ± 1.3b	137 ± 24b	5.9 ± 1.1b	24.9 ± 8.0a	157 ± 32b	187 ± 62a	0.95 ± 0.12b
Mild	28	8.7 ± 1.5	167 ± 28			7.3 ± 1.3	30.3 ± 9.8	192 ± 37
Severe	7	0.8 ± 0.4d	19 ± 9d	0.9 ± 0.7d	3.4 ± 1.3c	19 ± 10d	17 ± 9d	0.76 ± 0.36
Control	17	1.3 ± 0.5	29 ± 11			0.7 ± 0.5	4.2 ± 1.7	20 ± 10

^aP < 0.05,

^bP < 0.01, vs control;

^cP < 0.05,

^dP < 0.01, vs mild asphyxia.

Table 3 24-h pH monitoring of stomach in asphyxia (mean ± SD)

Group	n	Gastric index	Alkaline episodes	Episode > 5 min	Duration of longest episode pH > 4	Total time pH > 4	Area under pH > 4 curve
Asphyxia	35	21 ± 6	111 ± 17	10.1 ± 1.7	243 ± 59	554 ± 79	1132 ± 202
Mild	28	23 ± 7	124 ± 20	10.3 ± 1.8	234 ± 58	558 ± 83	1102 ± 188
Severe	7	15 ± 13	56 ± 24	9.3 ± 5.3	281 ± 196	539 ± 230	1252 ± 723
Control	17	20 ± 7	80 ± 17	8.7 ± 2.1	388 ± 96	802 ± 124	1769 ± 352