Microbiota-nutrition sequential therapy for refractory radiation proctitis: A case report

Table 1 Vienna Rectoscopy Score

Score	Congested mucosa	Telangiectasia	Ulceration	Stricture	Necrosis
0	Grade 1	None	None	None	None
1	Grade 2	Grade 1	None	None	None
2	Grade 3	Grade 2	None	None	None
3	Any grade	Grade 3	Grade 1	None	None
4	Any grade	Any grade	Grade 2	Grade 1	None
5	Any grade	Any grade	≥ Grade 3	≥ Grade 2	Present

Full grading definitions of the Vienna Rectoscopy Score are detailed in the main text.

Table 2 Common terminology criteria for adverse events of radiation proctitis

Grade	Clinical standards and intervention measures
Grade 1	Rectal discomfort; intervention not indicated
Grade 2	Symptoms (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental activities of daily living
Grade 3	Severe symptoms; fecal urgency or stool incontinence; limiting self-care activities of daily living
Grade 4	Life-threatening consequences; urgent intervention indicated
Grade 5	Death

Table 3 Baseline characteristics

	Pre-FMT	FMT1	FMT2
BMI (kg/m2)	20.28	22.31	24.34
Total protein (g/L)	63.7	68.3	73.7
Albumin (g/L)	35.8	36.7	40.0
Hemoglobin (g/L)	112	120	122
Lymphocyte count (109/L)	0.94	1.14	1.37
White blood cell count (109/L)	5.17	3.54	3.94
Lymphocyte percentage (%)	18.2	32.1	34.8
Vienna Rectoscopy Score	25	16	5
Proctitis grading (CTCAE grade)	Grade 3	Grade 2	Grade 1
PCT (ng/mL)	0.07	0.06	0.03

Pre-FMT: Before fecal microbiota transplantation; FMT1: Colonoscopy reexamined 1 month after the first fecal microbiota transplantation course; FMT2: Colonoscopy reexamined 2 months after the second fecal microbiota transplantation course; BMI: Body mass index; VRS: Vienna Rectoscopy Score; PCT: Procalcitonin; CTCAE: Common Terminology Criteria for Adverse Events.