Cladosporium cladosporioides ameliorates visceral hypersensitivity in irritable bowel syndrome-like mice by inhibiting dectin-1 signaling and mast cell activation

doi:10.3748/wjg.119605

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 14, 2026; 32(34): 119605
Published online Sep 14, 2026. doi: 10.3748/wjg.119605

Table 1 Characteristics of study participants, n (%)/mean ± SD

	IBS (n = 14)	Healthy controls (n = 12)
Age	49.0 ± 12.0	49.9 ± 8.4
Sex (% females)	7 (50.0)	7 (58.3)
BMI	22.4 ± 3.5	22.2 ± 2.9
Alcohol use	2 (14.3)	1 (8.3)
Current smoker	1 (7.1)	1 (8.3)
HADS depression score	3.9 ± 2.1	3.5 ± 1.9
HADS anxiety score	4.6 ± 2.6	3.3 ± 2.1
Medication use (%)
PPI	1 (7.1)	-
Probiotics	1 (7.1)	-
SSRI	0	-
Spasmolytics	1 (7.1)	-
Antibiotics	0	-
Diet model (% vegetarian)	8 (57.1)	5 (41.7)
IBS-SSS score	233.7 ± 131.1	-
Abdominal pain	54.6 ± 15.5
Bloating	54.9 ± 15.8
Abdominal pain frequency	55 ± 26
Bowel dissatisfaction	60.0 ± 19.3
Quality of life	59.2 ± 18.3
Diarrhea frequency > 4 times/week (%)	11 (78.6)	-

IBS: Irritable bowel syndrome; BMI: Body mass index; HADS: Hospital Anxiety and Depression Scale; PPI: Protein-protein interaction; SSRI: Selective serotonin reuptake inhibitor; IBS-SSS: Irritable bowel syndrome severity scoring system.

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Citation: Guo CL, Zhang SQ, Zheng HN, Chi Y, Wang HH. Cladosporium cladosporioides ameliorates visceral hypersensitivity in irritable bowel syndrome-like mice by inhibiting dectin-1 signaling and mast cell activation. World J Gastroenterol 2026; 32(34): 119605
URL: https://www.wjgnet.com/1007-9327/full/v32/i34/119605.htm
DOI: https://dx.doi.org/10.3748/wjg.119605

Guo CL, Zhang SQ, Zheng HN, Chi Y, Wang HH. Cladosporium cladosporioides ameliorates visceral hypersensitivity in irritable bowel syndrome-like mice by inhibiting dectin-1 signaling and mast cell activation. World J Gastroenterol 2026; 32(34): 119605 [DOI: 10.3748/wjg.119605]

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