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©The Author(s) 2024.
World J Gastroenterol. Feb 28, 2024; 30(8): 969-983
Published online Feb 28, 2024. doi: 10.3748/wjg.v30.i8.969
Published online Feb 28, 2024. doi: 10.3748/wjg.v30.i8.969
Table 1 The top 15 most cited scholars in gastric organoid field
Rank | Author | Publications | Citations | Country | Centrality |
1 | Clevers, Hans | 30 | 5144 | Netherland | 0.08 |
2 | Huch, Meritxell | 10 | 3987 | German | 0.04 |
3 | Van es, Johan | 7 | 3244 | Netherland | 0.00 |
4 | Van de Wetering, Marc | 6 | 3175 | Netherland | 0.00 |
5 | Sato, Toshiro | 14 | 3141 | Japan | 0.08 |
6 | Stange, Daniel | 12 | 1764 | German | 0.01 |
7 | Barker, Nick | 13 | 1707 | Netherland | 0.03 |
8 | Koo, Bon-kyoung | 15 | 1618 | Netherland | 0.25 |
9 | Bartfeld, Sina | 13 | 1405 | German | 0.03 |
10 | Zavros, Yana | 46 | 1312 | United States | 0.04 |
11 | Wells, James | 22 | 1040 | United States | 0.01 |
12 | Spence, Jason | 7 | 973 | United States | 0.00 |
13 | Peek, Richard | 5 | 715 | United States | 0.05 |
14 | Schumacher, Michael | 6 | 657 | Japan | 0.00 |
15 | Chen, Zheng | 12 | 615 | United States | 0.03 |
Table 2 The top 15 most cited institutions in gastric organoid field
Rank | Institution | Country | Publications | Citations | Centrality |
1 | University Medical Center Utrecht | Netherland | 19 | 5083 | 0.18 |
2 | Netherlands Institute for Developmental Biology Utrecht | Netherland | 8 | 3064 | 0.00 |
3 | University of Cincinnati | United States | 33 | 1451 | 0.25 |
4 | University of Hong Kong | Hongkong, China | 6 | 1148 | 0.08 |
5 | University of Michigan | United States | 22 | 1104 | 0.04 |
6 | Cincinnati Children’s Hospital Medical Center | United States | 16 | 999 | 0.07 |
7 | Columbia University | United States | 11 | 986 | 0.05 |
8 | Vanderbilt University | United States | 22 | 941 | 0.25 |
9 | Stanford University | United States | 11 | 881 | 0.02 |
10 | Cambridge University | United Kingdom | 7 | 758 | 0.08 |
11 | Harvard University | United States | 12 | 731 | 0.08 |
12 | Shinshu University | Japan | 17 | 625 | 0.07 |
13 | Keio University | Japan | 13 | 602 | 0.13 |
14 | Nanjing med University | China | 14 | 600 | 0.20 |
15 | Miami University | United States | 7 | 556 | 0.00 |
Table 3 The 20 most popular keywords in the field of gastric organoids
Keyword | Freq | Centrality |
Gastric cancer | 177 | 0.06 |
Stem cell | 110 | 0.04 |
Cancer stem cell | 45 | 0.10 |
Differentiation | 41 | 0.06 |
Helicobacter pylori | 32 | 0.01 |
Metastasis | 30 | 0.19 |
Proliferation | 30 | 0.04 |
Resistance | 29 | 0.06 |
Epithelial cell | 27 | 0.16 |
Self-renewal | 26 | 0.11 |
Apoptosis | 22 | 0.07 |
Progression | 22 | 0.04 |
Protein | 20 | 0.03 |
Progenitor cell | 18 | 0.04 |
Gene expression | 18 | 0.05 |
Chief cell | 17 | 0.04 |
Migration | 16 | 0.01 |
Chemotherapy | 16 | 0.07 |
Epithelial mesenchymal transition | 14 | 0.02 |
Mutation | 15 | 0.03 |
Table 4 The typical labels in each cluster
No. | Cluster label | Year | Label |
0 | Stem cell | 2015 | Stem cell; cancer; differentiation; model; acid gastric cancer; signet ring carcinoma; matrix metalloproteinase; spdef; transcription factor; stem cell; regeneration; gastric cancer; progenitor; in vitro expansion |
1 | Mouse | 2018 | Gastric cancer; transcription factor; regeneration; tumor suppressor genes; identification in vitro; expansion; liver; leptin deficiency; en-y gastric bypass; mouse; liver; infection; bariatric surgery; gastrointestinal cancer |
2 | Noncanonical nuclear factor-kappa B | 2019 | Gastric cancer; her2; capecitabine; open label; oxaliplatin drug screening; cancer organoids; precision medicine; Helicobacter pylori; living biobanks; cancer organoids; organoid; drug screenin; tptep1; secretion |
3 | Gastric cancer | 2013 | Gene; differentiation; receptor; lgr5; r spondin, gastric cancer; morphogenetic protein; epidermal growth factor receptor; Helicobacter pylori; tissue engineering; tumor microenvironment; receptor; gastric intestinal metaplasia; gene; csc markers (6.04, 0.05) |
4 | Targeted therapy | 2016 | Gastric cancer; cancer stem cell; endothelial growth; mammary stem cell; gastric cancers, cancer stem cells; translational research; tumor suppressor genes; gastric organoids; cancer microenvironment; abcg2; cancer stem cell; lgr4; acbp-3; cycle arrest |
5 | Polypeptide expression | 2017 | Cancer; progression; microenvironment; mmp 9; angiogenesis, gene expression; endoderm; gastrointestinal tract; mouse small intestine; gata4; gene expression; angiogenesis; epstein barr virus; toripalimab; mmp 9 |
6 | Cell | 2015 | Goblet cell carcinoid; crypt cell adenocarcinoma; appendix; mucinous; neuroendocrine; amphophilic; crypt cell adenocarcinoma; appendix; amphophilic; mucinous; neuroendocrine |
7 | Expression | 2012 | Survival; tumor suppressor; her2; poor prognosis; amplification, organoids; stomach; chemotherapy; gastroids; proliferation; amplification; gastroids; myc; inactivation; conditional mouse model |
8 | Synthetic lethality | 2019 | Gastric cancer; gastric organoids; gland fission; gastric stem cells; mtor; mtor; gland fission; gastric stem cells; gastric organoids; gastric cancer |
9 | Autophagy | 2014 | Gastric cancer; Helicobacter pylori; base excision repair; stomach neoplasms; gastric stem cells, nf kappa; trefoil protein; Helicobacter pylori; robust model; atrophic gastritis; NF kappa b; Helicobacter pylori; inflammation; antral epithelium; dynamic histology |
10 | Cancer organoids | 2020 | Gastric cancer; resistance; cancer; cetuximab; heterogeneity, cancer stem cell; lauren classification; mucin phenotype expression; cluster; transcription factor; gastric cancer; cd44; stomach; cancer stem cell; chemoresistance |
11 | Tumor microenvironment | 2017 | Gastric cancer; t-cell infiltration; recombinant protein; precision oncology; cancer model, stem cell; stomach; promote; cancer; gene expression; targeted therapy; self-renewa; promote; anti-egfr single domain antibody; cancer evolution |
12 | abcg 2 | 2012 | Gastric cancer; cancer stem cells; Helicobacter pylori; beta catenin; wound repair identification; stem cell; expression; inhibition; stomach; polypeptide expressing metaplasia; contribute; network; immune response; inhibition |
13 | Gene expression | 2013 | Gastric cancer; drug sensitivity; shaker; albumin-bound paclitaxel; stomach, breast cancer; model; growth; drug; identification; cell; breast cancer; growth; recombinant protein; irgd |
14 | Crypt cell adenocarcinoma | 2018 | Expression; stomach; stem cell; identification; progenitor cell, gastric cancer; stem cells; cancer biology; beta-galactoside alpha; sialic acid; expression; identification; pathogenesis; metaplasia; progenitor cell |
15 | Amplification | 2015 | Gastric cancer; cell adhesion; cell matrix interaction; magnetic resonance imaging; hereditary diffuse gastric cancer, synthetic lethality; discoidin domain receptor; diffuse gastric cancer; magnetic resonance imaging; hereditary diffuse gastric cancer; synthetic lethality; hdgc; e cadherin; e-cadherin; chemoprevention |
16 | mTOR | 2015 | Gastric cancer; stem-like subtype; adult mouse; cluster; cathepsin c ovarian; shaker; dynamic; fluid; peritoneal; autophagy; hypoxia inducible factor 1 alpha; cancer; metastasis; fibroblasts |
Table 5 The Top10 co-cited literature
Ref. | Title | Journal | Freq | Centrality |
Bartfeld et al[6], 2015 | In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection | Gastroenterology | 50 | 0.10 |
Bray et al[24], 2018 | Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries | CA Cancer J Clin | 49 | 0.00 |
Yan et al[9], 2018 | A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening | Cell Stem Cell | 45 | 0.05 |
Vlachogiannis et al[21], 2018 | Patient-derived organoids model treatment response of metastatic gastrointestinal cancers | Science | 43 | 0.06 |
Seidlitz et al[22], 2019 | Human gastric cancer modelling using organoids | GUT | 43 | 0.02 |
Schlaermann et al[7], 2016 | A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro | GUT | 37 | 0.09 |
Mccracken et al[20], 2014 | Modelling human development and disease in pluripotent stem-cell-derived gastric organoids | Nature | 35 | 0.05 |
Nanki et al[23], 2018 | Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis | Cell | 32 | 0.07 |
Cancer Genome Atlas Research Network[26], 2014 | Comprehensive molecular characterization of gastric adenocarcinoma | Nature | 31 | 0.05 |
Stange et al[19], 2013 | Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium | Cell | 28 | 0.12 |
- Citation: Jiang KL, Jia YB, Liu XJ, Jia QL, Guo LK, Wang XX, Yang KM, Wu CH, Liang BB, Ling JH. Bibliometrics analysis based on the Web of Science: Current trends and perspective of gastric organoid during 2010-2023. World J Gastroenterol 2024; 30(8): 969-983
- URL: https://www.wjgnet.com/1007-9327/full/v30/i8/969.htm
- DOI: https://dx.doi.org/10.3748/wjg.v30.i8.969