Clinical value of the Toronto inflammatory bowel disease global endoscopic reporting score in ulcerative colitis

Table 1 Patient demographic and clinical characteristics

Characteristics	Values (n = 166)
Gender, n (%)
Male	98 (59.0)
Female	68 (41.0)
Age (yr)	42.29 ± 12.05
BMI (kg/m2)	22.49 ± 3.47
Duration (mo)	36.0 (12.0, 96.0)
Montreal classification, n (%)
E1 = proctitis	21 (12.7)
E2 = left-sided colitis	47 (28.3)
E3 = extensive colitis	98 (59.0)
Truelove and Witts Severity Index, n (%)
Mild	44 (26.5)
Moderate	51 (30.7)
Severe	71 (42.8)
Total TIGER score	214 (109, 324)
UCEIS score	5 (3, 6)
MES	3 (2, 3)
Treatment, n (%)
5-ASAs	161 (97.0)
Systemic corticosteroids	40 (24.1)
IFX	8 (4.8)
VDZ	10 (6)
Immunomodulators	3 (1.8)
Tofacitinib	2 (1.2)
Thalidomide	2 (1.2)
Colectomy	1 (0.6)
Length of hospitalization (d)	7.00 (4.75-10.00)
Hospitalisation costs (CNY)	9088.11 (6788.40-12500.72)
Readmission within 1 yr, n (%)	48 (33.8)
CRP (mg/L)	3.58 (1.44-9.96)
ESR (mm/60 min)	10 (6-18)
WBC (× 109/L)	6.95 (5.53-8.62)
NE (× 109/L)	4.29 (3.03-5.59)
LYM (× 109/L)	1.81 (1.45-2.27)
PLT (× 109/L)	273.50 (216.75-365.50)
Hb (g/L)	127.00 (104.75-143.00)
Alb (g/L)	42.65 (37.50-54.10)
BUN (mmol/L)	3.96 (3.01-5.02)
UA (µmol/L)	296.39 ± 103.49
Cr (µmol/L)	57.50 (49.00-69.00)

BMI: Body mass index; TIGER: Toronto Inflammatory Bowel Disease Global Endoscopic Reporting; UCEIS: Ulcerative Colitis Endoscopic Index of Severity; MES: Mayo Endoscopic Subscore; 5-ASAs: 5-Aminosalicylates; IFX: Infliximab; VDZ: Vedolizumab; CRP: C-reactive protein; CNY: Chinese Yuan; ESR: Erythrocyte sedimentation rate; WBC: White blood cell; NE: Neutrophil count; LYM: Lymphocyte count; PLT: Platelet count; Hb: Haemoglobin; Alb: Albumin; BUN: Urea nitrogen; UA: Uric acid; Cr: Creatinine.

Table 2 Correlations between three endoscopic scores and laboratory/clinical parameters

Parameters	TIGER score		UCEIS score		MES
	Spearman coefficient (r)	P value	Spearman coefficient (r)	P value	Spearman coefficient (r)	P value
BMI	-	0.146	-	0.035	-	0.191
Duration	-	0.660	-	0.604	-	0.814
CRP	0.639	< 0.001	0.622	< 0.001	0.509	< 0.001
ESR	0.551	< 0.001	0.540	< 0.001	0.351	< 0.001
WBC	0.387	< 0.001	0.319	< 0.001	0.268	< 0.001
NE	0.458	< 0.001	0.369	< 0.001	0.310	< 0.001
LYM	-	0.349	-	0.823	-	0.790
PLT	0.429	< 0.001	0.395	< 0.001	0.248	< 0.001
Hb	-0.353	< 0.001	-0.388	< 0.001	-0.245	0.001
Alb	-0.422	< 0.001	-0.306	< 0.001	-0.278	< 0.001
BUN	-0.320	< 0.001	-0.295	< 0.001	-0.251	0.001
UA	-	0.233	-0.164	0.035	-	0.510
Cr	-	0.305	-	0.399	-	0.144
Stay	0.488	< 0.001	0.494	< 0.001	0.339	< 0.001
Costs	0.376	< 0.001	0.375	< 0.001	0.270	< 0.001

BMI: Body mass index; TIGER: Toronto Inflammatory Bowel Disease Global Endoscopic Reporting; UCEIS: Ulcerative Colitis Endoscopic Index of Severity; MES: Mayo Endoscopic Subscore; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; WBC: White blood cell; NE: Neutrophil count; LYM: Lymphocyte count; PLT: Platelet count; Hb: Haemoglobin; Alb: Albumin; BUN: Urea nitrogen; UA: Uric acid; Cr: Creatinine.

Table 3 Univariable analysis of risk factors for the advanced treatment, n (%)

Variables	5-ASAs-alone group (n = 113)	Advanced treatment group (n = 53)	P value
Age			0.373
< 40 yr	45 (39.8)	25 (47.2)
≥ 40 yr	68 (60.2)	28 (52.8)
Sex			0.054
Male	61 (54.0)	37 (69.8)
Female	52 (46.0)	16 (30.2)
Extent			< 0.001
E1 or E2	65 (57.5)	3 (5.7)
E3	48 (42.5)	50 (94.3)
CRP			< 0.001
< 5 mg/L	85 (75.2)	14 (26.4)
≥ 5 mg/L	28 (24.8)	39 (73.6)
Hb			< 0.001
≥ 110 g/L	94 (83.2)	26 (49.1)
< 110 g/L	19 (16.8)	27 (50.9)
Truelove and Witts index			< 0.001
Mild or moderate	84 (74.3)	11 (20.8)
Severe	29 (25.7)	42 (79.2)
TIGER score			< 0.001
< 317	98 (86.7)	16 (30.2)
≥ 317	15 (13.3)	37 (69.8)
UCEIS score			< 0.001
< 6	94 (83.2)	21 (39.6)
≥ 6	19 (16.8)	32 (60.4)
MES			< 0.001
≤ 2	68 (60.2)	14 (26.4)
> 2	45 (39.8)	39 (73.6)

TIGER: Toronto Inflammatory Bowel Disease Global Endoscopic Reporting; UCEIS: Ulcerative Colitis Endoscopic Index of Severity; MES: Mayo Endoscopic Subscore; 5-ASAs: 5-Aminosalicylates; CRP: C-reactive protein; Hb: Haemoglobin.

Table 4 Multi-variable logistic regression analysis for the risk factors of the advanced treatment

Variables	Odds ratio	95%CI	P value
Extent, E3	6.488	1.617-26.027	0.008
CRP ≥ 5 mg/L	2.554	0.956-6.819	0.061
Hb < 110 g/L	1.736	0.615-4.899	0.297
Truelove and Witts Index, Severe	1.390	0.452-4.278	0.566
TIGER score ≥ 317	3.891	1.360-11.136	0.011
UCEIS score ≥ 6	2.171	0.736-6.403	0.160
MES > 2	0.945	0.335-2.667	0.914

95%CI: 95% confidence interval; CRP: C-reactive protein; Hb: Haemoglobin; TIGER: Toronto Inflammatory Bowel Disease Global Endoscopic Reporting; UCEIS: Ulcerative Colitis Endoscopic Index of Severity; MES: Mayo Endoscopic Subscore.