Global burden of inflammatory bowel disease 1990-2019: A systematic examination of the disease burden and twenty-year forecast

Table 1 Incidence and age-standardized incidence of inflammatory bowel disease in various regions of the world from 1990-2019 and temporal trends from 1990-2019

Region	1990		2019		1990-2019
	Incident cases, No. (95%UI)	ASR per 100000, No. (95%UI)	Incident cases, No. (95%UI)	ASR per 100000, No. (95%UI)	EAPC, No. (95%CI)
Africa	6350.4 (5449.9-7409.6)	1.4 (1.2-1.6)	16261.3 (13488.9-19647.2)	1.6 (1.4-2)	0.41 (0.35-0.47)
African Region	3832.8 (3242.9-4587.4)	1.1 (1-1.3)	10258.1 (8583.6-12449.3)	1.3 (1.1-1.6)	0.52 (0.46-0.57)
America	121311.1 (106225.2-139803.3)	17.8 (15.6-20.4)	122924.6 (112507.2-135597.1)	11.1 (10.1-12.2)	-1.3 (-1.64 to -0.96)
Andean Latin America	472.1 (401.7-549.7)	1.6 (1.4-1.9)	1128.2 (974.6-1314.4)	1.8 (1.6-2.1)	-0.05 (-0.28-0.19)
Asia	64767.7 (54186.2-76818.5)	2.3 (2-2.8)	145560.7 (124960.3-170895)	2.9 (2.5-3.4)	0.78 (0.69-0.86)
Australasia	2979 (2555.6-3481.3)	13.6 (11.6-15.8)	6446.3 (5754.6-7211.5)	20 (17.8-22.6)	0.94 (0.73-1.15)
Caribbean	676.8 (580.4-796)	2.1 (1.8-2.5)	1311.8 (1121-1571.1)	2.6 (2.2-3.1)	0.49 (0.34-0.63)
Central Asia	3514.1 (2995-4146.2)	6 (5.1-7.1)	6461.3 (5487.2-7636.7)	6.9 (5.9-8.1)	0.5 (0.46-0.53)
Central Europe	20996.8 (18082.3-24169.9)	15.8 (13.6-18.2)	14808.9 (13442.8-16390.5)	11.6 (10.5-12.8)	-1.38 (-1.75 to -1.01)
Central Latin America	3967.5 (3401.5-4617.8)	3.2 (2.7-3.7)	6753.6 (5833.6-7825.9)	2.6 (2.3-3.1)	-0.7 (-0.86 to -0.54)
Central Sub-Saharan Africa	381.4 (318.5-468.6)	1 (0.9-1.3)	1149.7 (954.9-1399.8)	1.3 (1.1-1.5)	0.64 (0.59-0.69)
Commonwealth High Income	26861.8 (24786.3-29244.5)	22.3 (20.6-24.2)	37806 (34948.3-41071.2)	24.5 (22.6-26.6)	0.42 (0.33-0.52)
Commonwealth Low Income	1939.8 (1595.5-2362)	1.4 (1.1-1.7)	5032.5 (4152.5-6067.4)	1.6 (1.4-2)	0.61 (0.56-0.66)
Commonwealth Middle Income	18395 (15168.4-22494.1)	2 (1.7-2.4)	39643.1 (33048-48435)	2.1 (1.8-2.6)	0.44 (0.3-0.58)
East Asia	17567.3 (14626.9-20802.4)	1.4 (1.2-1.7)	52318.8 (44680.4-61454.8)	3 (2.5-3.4)	2.54 (2.4-2.68)
East Asia & Pacific - WB	40537 (34343.4-47828.7)	2.3 (2-2.7)	90853.2 (79210-104418.9)	3.4 (2.9-3.9)	1.16 (1.06-1.26)
Eastern Europe	18149.7 (15600.1-21209.1)	7.1 (6.1-8.3)	19499.8 (16838-22671)	7.3 (6.3-8.5)	0.07 (-0.01-0.16)
Eastern Mediterranean Region	6925.3 (5871.5-8131.4)	2.5 (2.1-2.9)	18957.5 (15653.5-22992.9)	2.9 (2.4-3.5)	0.54 (0.49-0.59)
Eastern Sub-Saharan Africa	1092.2 (908-1315.3)	0.9 (0.8-1.1)	2937.7 (2448.6-3538.4)	1 (0.9-1.3)	0.55 (0.49-0.61)
Europe	100967 (89900.9-113361.1)	11.5 (10.3-13)	119525.9 (108023.4-132990.6)	12.5 (11.3-14)	0.18 (0.11-0.26)
Europe & Central Asia - WB	103166.8 (91767-115892)	11.2 (10-12.7)	124122.3 (111829.4-138334.3)	12 (10.8-13.5)	0.13 (0.06-0.2)
European Region	103678.4 (92211.4-116480.8)	11.2 (10-12.6)	125055.7 (112703.8-139366)	12 (10.8-13.4)	0.12 (0.05-0.2)
High-income Asia Pacific	18105.1 (15391.4-21421.8)	9.2 (7.9-10.9)	27083.8 (23870.3-30621.1)	14.9 (13.1-16.9)	1.1 (0.85-1.36)
High-income North America	107616.3 (94146.8-123884.4)	34.9 (30.6-40)	99611.1 (91945.2-108999.8)	24.5 (22.6-26.8)	-0.82 (-1.18 to -0.47)
Latin America & Caribbean - WB	13797.5 (11970.2-15892.3)	3.8 (3.3-4.3)	23456.2 (20522.6-26876.2)	3.4 (3-3.9)	-0.41 (-0.47 to -0.35)
Middle East & North Africa - WB	5823.7 (5004.6-6721.7)	2.9 (2.5-3.4)	15826.6 (13170.5-19047.6)	3.4 (2.9-4.1)	0.5 (0.43-0.58)
North Africa and Middle East	8106.7 (7039.5-9203.5)	2.9 (2.6-3.4)	22722.3 (19277.1-26951.9)	3.7 (3.2-4.5)	0.62 (0.53-0.72)
North America	107604.1 (94136.5-123870)	34.9 (30.6-40)	99596.5 (91933-108983)	24.5 (22.6-26.8)	-0.82 (-1.18 to -0.47)
Oceania	22.5 (18.3-26.8)	0.4 (0.4-0.5)	63.2 (51.8-76.5)	0.6 (0.5-0.7)	0.87 (0.77-0.98)
Region of the Americas	121311.1 (106225.2-139803.3)	17.8 (15.6-20.4)	122924.6 (112507.2-135597.1)	11.1 (10.1-12.2)	-1.3 (-1.64 to -0.96)
South-East Asia Region	18276.9 (15080.6-22303.3)	1.7 (1.4-2.1)	38664.5 (32256.8-47052.4)	1.9 (1.6-2.3)	0.57 (0.42-0.73)
South Asia	18439.4 (15168.6-22581.9)	2.2 (1.8-2.6)	39704.7 (32943.4-48453.5)	2.3 (1.9-2.8)	0.47 (0.32-0.62)
South Asia - WB	18738.6 (15412.5-22942.5)	2.1 (1.8-2.6)	40659.5 (33741.9-49588.8)	2.3 (1.9-2.8)	0.49 (0.34-0.64)
Southeast Asia	1882 (1527.1-2270.3)	0.5 (0.4-0.6)	4980 (4181.8-5972.3)	0.7 (0.6-0.8)	1.45 (1.28-1.62)
Southern Latin America	879.4 (741.6-1029.7)	1.8 (1.5-2.1)	1382 (1177.4-1619.7)	1.9 (1.6-2.3)	0.24 (0.15-0.33)
Southern Sub-Saharan Africa	503.7 (422.7-607.5)	1.3 (1.1-1.6)	988.7 (837.3-1188)	1.4 (1.2-1.6)	0.13 (0.07-0.2)
Sub-Saharan Africa - WB	3626.5 (3031.8-4397.1)	1.1 (0.9-1.3)	9635 (8053-11630.3)	1.2 (1-1.5)	0.42 (0.34-0.5)
Tropical Latin America	7825.7 (6858.8-8975.6)	6.1 (5.4-6.9)	12927.7 (11333.6-14873.9)	5.2 (4.6-6)	-0.55 (-0.59 to -0.51)
Western Europe	59080.5 (53732.6-65528.7)	14 (12.7-15.5)	78644.7 (71611.1-86708.9)	16.9 (15.3-18.7)	0.6 (0.56-0.65)
Western Pacific Region	39273.1 (33180.5-46324.7)	2.6 (2.2-3.1)	88120.1 (76953.2-101217.2)	4 (3.5-4.5)	1.25 (1.15-1.35)
Western Sub-Saharan Africa	1313.7 (1101.9-1598.6)	1 (0.9-1.2)	3628.3 (3028.5-4400.8)	1.2 (1-1.4)	0.36 (0.22-0.49)
World Bank High Income	206040 (182079.4-234728.1)	18.8 (16.6-21.4)	225597.7 (206227.4-249141.7)	17.1 (15.6-18.9)	-0.24 (-0.39 to -0.08)
World Bank Low Income	2388.3 (1998.4-2891.8)	1 (0.9-1.3)	6306.6 (5252.9-7655.6)	1.2 (1.1-1.5)	0.56 (0.52-0.6)
World Bank Lower Middle Income	30142.4 (25192.1-36034.9)	2 (1.7-2.4)	63401.3 (53275.5-76198.6)	2.1 (1.8-2.6)	0.29 (0.2-0.37)
World Bank Upper Middle Income	54916.9 (47252.2-63473.1)	2.8 (2.5-3.3)	109097 (94356.3-126861)	3.5 (3.1-4.1)	0.74 (0.67-0.8)

ASR: Age standardized rate; CI: Confidence interval; EAPC: Estimated annual percentage change; UI: Uncertainty interval.