Ji-Chuan decoction ameliorates slow transit constipation via regulation of intestinal glial cell apoptosis

Table 1 Dry weight, wet weight and moisture content of feces of mice in each group

Grouping/feces index	Wet weight (g/mou)	Dry weight (g/mou)	Moisture content (%/mou)
HC	0.26 ± 0.02	0.18 ± 0.01	0.30 ± 0.04
STC	0.12 ± 0.01a	0.10 ± 0.01c	0.18 ± 0.01c
JCDL	0.25 ± 0.01	0.18 ± 0.01	0.29 ± 0.02
JCDM	0.26 ± 0.02a	0.18 ± 0.02c	0.30 ± 0.02c
JCDH	0.26 ± 0.02a	0.18 ± 0.01c	0.31 ± 0.02c
MSP	0.27 ± 0.03b	0.19 ± 0.02c	0.30 ± 0.01c

^aP < 0.05: Compared with the healthy control group.

^bP < 0.01: Compared with the healthy control group.

^cP < 0.05: Compared with the slow transit constipation group.

Data are expressed as the mean ± SD. HC: Healthy control; STC: Slow transit constipation; JCD: Ji-Chuan decoction; JCDL: Low-dose Ji-Chuan decoction treatment; JCDM: Middle-dose Ji-Chuan decoction treatment; JCDH: High-dose Ji-Chuan decoction treatment; MSP: Mosapride treatment.

Table 2 The core ingredients of Ji-Chuan decoction

Molecular name	Oral bioavailability (%)	Drug like
Baicalein	33.52	0.21
Kaempferol	41.88	0.24
Naringenin	59.29	0.21
Quercetin	46.43	0.28
Wogonin	30.68	0.23