Zhang YC, Li M, Jin YM, Xu JX, Huang CC, Song B. Radiomics for differentiating tumor deposits from lymph node metastasis in rectal cancer. World J Gastroenterol 2022; 28(29): 3960-3970 [PMID: 36157536 DOI: 10.3748/wjg.v28.i29.3960]
Corresponding Author of This Article
Bin Song, MD, PhD, Chief Doctor, Professor, Department of Radiology, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, Sichuan Province, China. songlab_radiology@163.com
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 7, 2022; 28(29): 3960-3970 Published online Aug 7, 2022. doi: 10.3748/wjg.v28.i29.3960
Table 1 Baseline and clinical characteristics of the included patients
Characteristics
TDs+LNM-(n = 89)
LNM+TDs– (n = 115)
P value
Training set (n = 163)
Validation set (n = 41)
P value
Age (mean ± SD, yr)
59 ± 12
61 ± 12
0.268
60 ± 12
60 ± 11
0.965
Gender (man/woman)
49/40
63/52
0.969
94/69
18/23
0.113
Location (middle-low/high)
65/24
74/41
0.187
107/56
32/9
0.128
Neoadjuvant therapy (+/-)
34/55
43/72
0.906
62/101
15/26
0.864
CEA (+/-) (positive ≥ 5 ng/mL)
42/47
43/72
0.159
75/88
10/31
0.012
CA19-9 (+/-) (positive ≥ 30 U/mL)
23/66
18/97
0.072
34/129
7/34
0.589
CA125 (+/-) (positive ≥ 24 U/mL)
13/76
14/101
0.611
21/142
6/35
0.767
pT stage (T1/T2/T3/T4)
0/9/70/10
4/12/93/6
0.063
4/17/127/15
0/4/36/1
0.894
pN stage (1a/1b/1c/2a/2b)
0/0/89/0/0
52/39/0/15/9
< 0.001
37/33/71/13/9
15/6/18/2/0
0.115
Histologic EMVI (+/-)
33/56
16/99
< 0.001
41/122
8/33
0.450
Histologic grade (G1/G2/G3)
1/63/25
0/76/39
0.299
0/113/50
1/26/14
0.901
Peritumoral nodule
Shape (irregular/regular)
12/77
2/113
0.003
11/152
3/38
0.898
Spiculation (+/-)
7/82
2/113
0.077
7/156
2/39
0.871
Size (mm2) (median)
72.7
41.2
< 0.001
54
43
0.886
CT value (HU)
61 ± 22
65 ± 23
0.258
64 ± 23
63 ± 23
0.858
Rad-score 1 (median)
0.71
0.39
< 0.001
0.44
0.71
0.002
Rad-score 2 (median)
0.89
0.13
< 0.001
0.39
0.62
0.561
Table 2 Univariate and multivariate logistic regression analysis
Variables
Univariate
Multivariate
OR
P value
OR
P value
Age
0.995
0.693
-
-
Gender
0.820
0.534
-
-
Location
0.819
0.282
-
-
CEA
1.546
0.171
-
-
CA19-9
1.613
0.217
-
-
CA125
1.503
0.384
-
-
Peritumoral nodule
Shape
14.918
0.011
0.915
0.948
Spiculated (+/-)
8.400
0.051
-
-
Size (mm2)
1.009
0.001
0.999
0.314
CT value (HU)
0.994
0.364
-
-
Rad-score 1
2.946
< 0.001
3.267
< 0.001
Rad-score 2
11.979
< 0.001
14.396
< 0.001
Table 3 Comparisons of the models in the training, validation, and mixed groups
Training set
Validation set
Mixed group
AUC
SEN
SPE
P value
AUC
SEN
SPE
P value
SEN
SPE
Accuracy
Rad-score 1
0.768 (95%CI: 0.695-0.830)
66.2%
70.7%
< 0.001
0.700 (95%CI: 0.537-0.833)
77.8%
47.8%
0.032
-
-
-
Combined model
0.955 (95%CI: 0.910-0.981)
83.1%
88.0%
0.134
0.930 (95%CI: 0.805-0.986)
94.4%
82.6%
0.594
66.6%
73.3%
70.0%
Rad-score 2
0.940 (95%CI: 0.892-0.971)
83.1%
84.8%
0.918 (95%CI: 0.789-0.981)
83.3%
82.6%
73.3%
66.6%
70.0%
Table 4 Subgroup analyses of the models in single-positive patients
Rad-score 1
Rad-score 2
P value
Subgroups
AUC
SEN (%)
SPE (%)
AUC
SEN (%)
SPE (%)
nCRT
With (n = 77)
0.740 (95%CI: 0.628-0.833)
73.5%
74.4%
0.897 (95%CI: 0.806-0.954)
73.5%
90.7%
0.014
Without (n = 127)
0.753 (95%CI: 0.668-0.825)
60%
86.1%
0.957 (95%CI: 0.905-0.985)
89.1%
93.1%
< 0.001
Location
Mid-low (n = 139)
0.782 (95%CI: 0.704-0.848)
75.4%
62.2%
0.931 (95%CI: 0.875-0.967)
86.2%
82.4%
< 0.001
High (n = 65)
0.643 (95%CI: 0.515-0.758)
54.2%
73.2%
0.941 (95%CI: 0.853-0.984)
83.3%
85.4%
< 0.001
Number of TDs
1-2 (n = 50)
≥ 3 (n = 39)
P = 0.838
1-2 (n = 50)
≥ 3 (n = 39)
P = 0.309
Value
0.64 ± 0.24
0.65 ± 0.22
0.83 ± 0.22
0.77 ± 0.26
Citation: Zhang YC, Li M, Jin YM, Xu JX, Huang CC, Song B. Radiomics for differentiating tumor deposits from lymph node metastasis in rectal cancer. World J Gastroenterol 2022; 28(29): 3960-3970