Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis

Table 1 Characteristics of patients with ulcerative colitis, Crohn’s disease, and acute enteritis and healthy volunteers

Characteristic	Patients with UC	Patients with CD	Patients with AE	HVs	CRP-high HVs
Number (male:female)	110 (63:47)	45 (36:9)	11 (5:6)	20 (14:6)	79 (56:26)
Age, yr, mean (SD)	48.79 (15.08)	46.24 (11.75)	42.89 (20.20)	53.05 (6.58)	56.01 (11.23)
Age at IBD diagnosis, yr, mean (SD)	34.74 (16.64)	26.89 (8.36)
UC disease location, extensive colitis/left-sided colitis/proctitis	52/40/18
CD location, colic/ileal/ileo-colic		5/17/23
Alb, g/dL, mean (SD)	4.14 (0.31)	3.71 (0.51)	3.84 (0.41)	4.41 (0.19)	4.28 (0.24)
ALT, U/L, mean (SD)	20.27 (17.49)	16.00 (6.04)		37.00 (22.19)	16.96 (5.22)
ALP, U/L, mean (SD)	212.58 (69.81)	244.79 (88.12)		214.35 (54.46)	209.84 (56.33)
T-Bil, mg/dL, mean (SD)	0.51 (0.36)	0.45 (0.24)		0.77 (0.22)	0.63 (0.23)
γ-GTP, U/L, mean (SD)	30.75 (23.66)	22.67 (15.61)		42.78 (25.20)	28.97 (17.30)
CRP, mg/dL, mean (SD)	0.38 (0.61)	0.68 (1.16)	8.15 (2.46)	0.10 (0.08)	1.35 (0.85)
Hb, g/dL, mean (SD)	12.79 (1.87)	12.78 (1.75)	13.08 (1.75)	14.53 (1.05)	13.96 (1.32)
Ht, %, mean (SD)	38.91 (7.58)	39.65 (4.77)	39.11 (4.59)	42.6 (2.68)	40.79 (3.66)
WBC, 10³/µL, mean (SD)	7.35 (2.48)	6.75 (2.17)	12.50 (5.18)
Plt, 104/µL, mean (SD)	27.58 (7.07)	28.90 (6.21)	27.34 (6.22)	21.60 (5.62)	23.43 (6.45)
Mayo, mean (SD)	3.27 (2.83)
CDAI, mean (SD)		129.18 (70.48)

UC: Ulcerative colitis; CD: Crohn’s disease; AE: Acute enteritis; HVs: Healthy volunteers; Alb: Albumin; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; T-Bil: Total-bilirubin; γ-GTP: γ-Glutamyl transpeptidase; CRP: C-reactive protein; Hb: Hemoglobin; Ht: Hematocrit; WBC: White blood cells; Plt: Platelets; Mayo: Full Mayo score; CDAI: Crohn’s disease activity index; SD: Standard deviation.

Table 2 Correlation coefficients between 10-7G value and clinical parameters in ulcerative colitis and Crohn’s disease patients

	UC			CD
	rs	P value	n	rs	P value	n
Alb	-0.182	0.254	41	-0.376a	0.014	42
ALT	-0.214	0.339	22	-0.148	0.51	22
ALP	0.453	0.052	19	0.329	0.169	19
T-Bil	-0.419	0.059	21	-0.081	0.728	21
γ-GTP	-0.06	0.801	20	0.392	0.079	21
CRP	0.525a	0.0003	44	0.595a	< 0.0001	44
Hb	-0.308a	0.0419	44	-0.287	0.072	40
Ht	-0.304	0.064	38	-0.261	0.091	43
WBC	0.289	0.057	44	0.215	0.177	41
Plt	0.06	0.712	40	0.145	0.387	38
Mayo	0.435a	0.038	23
CDAI				0.134	0.392	43

rs: Spearman’s rank correlation coefficient.

^aP < 0.05. UC: Ulcerative colitis; CD: Crohn’s disease; Alb: Albumin; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; T-Bil: Total-bilirubin; γ-GTP: γ-Glutamyl transpeptidase; CRP: C-reactive protein; Hb: Hemoglobin; Ht: Hematocrit; WBC: White blood cells; Plt: Platelets; Mayo: Full Mayo score; CDAI: Crohn’s disease activity index.