Yang XJ, Liu D, Ren HY, Zhang XY, Zhang J, Yang XJ. Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients. World J Gastroenterol 2021; 27(19): 2376-2393 [PMID: 34040329 DOI: 10.3748/wjg.v27.i19.2376]
Corresponding Author of This Article
Xiao-Jun Yang, MM, Chief Doctor, Professor, Department of Critical Care Medicine, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan 750004, Ningxia Hui Autonomous Region, China. email@example.com
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APACHE II score: Acute Physiologic Assessment and Chronic Health Evaluation II Scoring System; SOFA score: Sequential Organ Failure Assessment Score; BMI: Body mass index.
aP < 0.05.
bP < 0.01.
Table 2 General clinical information of the patients in the sepsis group
Primary infection site
Categories of antibiotics used within 7 d after admission to the ICU
Carbapenems + glycopeptides
Carbapenems + oxazolidinones
Broad-spectrum penicillins + carbapenems
Broad-spectrum penicillins + glycopeptides
Broad-spectrum penicillins + tetracyclines
Carbapenems + broad-spectrum penicillins
Carbapenems + glycopeptides
Note: Sn represents the sepsis patient number n in the sepsis group; e.g., S1 represents sepsis patient No. 1. ICU: Intensive care unit.
Table 3 Pathogenic bacteria isolated in the sepsis group
Corresponding sample collection time (day n after admission to the ICU)
S5, S6, S8
4, 13, 23
Sn represents the sepsis patient number n in the sepsis group; e.g., S5 represents sepsis patient No. 5. In the table, sputum and blood samples from patients in the sepsis group were subjected to qualitative cultures, and bacterial colonization and contamination were ruled out. ICU: Intensive care unit.
Table 4 Statistical comparison of the α-diversity indexes of the intestinal flora in the three groups of individuals
Control-median vs non-sepsis-median
Control-median vs sepsis-median
Non-sepsis-median vs sepsis-median
The Ace and Chao indexes reflect the microbial abundances in samples. Larger values indicate higher microbial abundance. The Shannon and Simpson indexes reflect the microbial diversity of samples. A larger Shannon index indicates a higher diversity, whereas a larger Simpson index indicates a lower diversity. P < 0.05 was considered statistically significant. OTUs: Operational taxonomic units.
Table 5 Variation in the α-diversity indexes of the intestinal flora in patients with sepsis within 1 wk of treatment (days 1, 3, and 7 after intensive care unit admittance)
Day 1 vs day 3
Day 1 vs day 7
Day 3 vs day 7
OTUs: Operational taxonomic units.
Citation: Yang XJ, Liu D, Ren HY, Zhang XY, Zhang J, Yang XJ. Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients. World J Gastroenterol 2021; 27(19): 2376-2393