Copyright ©The Author(s) 2021.
World J Gastroenterol. May 7, 2021; 27(17): 1905-1919
Published online May 7, 2021. doi: 10.3748/wjg.v27.i17.1905
Table 1 List of registered clinical trials on the use of mesenchymal stromal cell-derived extracellular vesicles for tissue injury
Tissue injury disease
Trial ID
Chronic lung diseasePediatric bronchopulmonary dysplasiaBM-MSC-derived EVsNCT03857841Phase I
Lung diseasePneumonia, COVID-19BM-MSC-derived EVsNCT04493242Not yet recruiting
Lung diseasePneumonia, COVID-19Inhalation of mesenchymal stem cell exosomesNCT04276987Phase I
Multiple organ failure Multiple organ dysfunction syndromeMSC exosomesNCT04356300Not yet recruiting
Lung diseasePulmonary infectionMSC exosomesNCT04544215Recruiting
Dry eyeGVHDUC-MSC exosomesNCT04213248Recruiting
Cartilage injuryOsteoarthritisSecretome or EVs from adipose MSCsNCT04223622Not yet recruiting
Skin diseaseDystrophic epidermolysis bullosaBM-MSC EVsNCT04173650Phase II
BrainCerebrovascular disordersAllogenic MSCs enriched with miR-124NCT03384433Phase II