Retrospective Cohort Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Nov 21, 2020; 26(43): 6837-6852
Published online Nov 21, 2020. doi: 10.3748/wjg.v26.i43.6837
Table 1 Clinical characteristics of patients in the laparoscopic-assisted tailored subtotal gastrectomy and laparoscopic assisted total gastrectomy groups
CharacteristicLaTSG (n = 47)LaTG (n = 45)P value
Sex (M/F)11/3617/280.175
Age57.0 ± 11.158.0 ± 9.90.571
BMI (kg/m2)23.6 ± 3.423.7 ± 3.00.559
ASA-PS (1/2/3)2/44/12/42/10.998
pT stage0.027
pT118 (38.3)10 (22.2)
pT25 (10.6)4 (8.9)
pT38 (17.0)22 (48.9)
pT4a16 (34.0)9 (20.0)
pN stage0.371
pN023 (48.9)14 (31.2)
pN110 (21.3)14 (31.2)
pN26 (12.8)7 (15.6)
pN38 (17.0)10 (22.2)
pTNM stage0.217
I18 (38.3)11 (24.4)
II10 (21.3)16 (35.6)
III19 (40.4)18 (40.0)
Previous abdominal operation4 (8.5)1 (2.2)0.362
Neoadjuvant chemotherapy9 (19.1)6 (13.3)0.575
Histological type0.237
Signet-ring cell carcinoma20 (42.6)12 (26.7)0.187
Blood vessel invasion30 (63.9)30 (66.6)0.829
Neural infiltration26 (55.4)27 (60.0)0.532
Tumor location0.604
Lesser curvature25 (53.2)24 (53.4)
Middle3 (6.4)5 (11.1)
Middle and low19 (40.4)16 (35.6)
Table 2 Operative findings in the laparoscopic-assisted tailored subtotal gastrectomy and laparoscopic assisted total gastrectomy groups
VariableLaTSG (n = 44)LaTG (n = 58)P value
Operation time (min)210.0 ± 49.8208.0 ± 50.00.684
Estimated blood loss (mL)152.3 ± 166.1188.9 ± 167.80.141
Intraoperative blood transfusion6/478/450.570
Tumor size3.4 ± 1.24.5 ± 1.80.020
No. of retrieved lymph nodes31.8 ± 10.144.0 ± 16.50.008
Proximal margin3.7 ± 1.63.9 ± 2.00.233
Distal margin5.0 ± 2.66.2 ± 3.20.149
Table 3 Postoperative complications in the laparoscopic-assisted tailored subtotal gastrectomy and laparoscopic assisted total gastrectomy groups, n (%)
ComplicationLaTSG (n = 47)LaTG (n = 45)P value
Anastomotic leakage0 (0)3 (6.7)
Anastomotic stricture0 (0)1 (2.2)
Anastomotic bleeding0 (0)0 (0)
Duodenal stump leakage1 (2.1)0 (0)
Intra-abdominal bleeding0 (0)0 (0)
Intra-abdominal abscess1 (2.1)3 (6.7)
Lymph leak0 (0)1 (2.2)
Ileus0 (0)0 (0)
Incision0 (0)1 (2.2)
Total2 (4.2)8 (17.8)0.048
Mortality0 (0)1 (2.2)
Postoperative hospital stay8.9 ± 5.012.0 ± 7.30.025
Reflux esophagitis (LA)0.002
LA –B2 (4.2)5 (11.1)
LA-C0 (0)5 (11.1)
Table 4 Nutritional indexes of laparoscopic-assisted tailored subtotal gastrectomy and laparoscopic assisted total gastrectomy at 1 year postoperatively
VariableLaTSG (n = 47)LaTG (n = 45)P value
ALB (g/L)45.2 ± 3.745.1 ± 7.20.005
PALB (g/L)21.6 ± 4.718.5 ± 5.30.015
TP (g/L)71.0 ± 4.267.6 ± 4.60.002
Fe15.6 ± 5.713.4 ± 6.90.194
HGB (g/L)133 ± 20.7120.0 ± 20.10.007
RBC(1012/L)4.5 ± 0.74.0 ± 0.40.003
CRP0.37 ± 0.970.05 ± 0.250.187
Table 5 Univariate and multivariate analyses of overall survival for included patients
VariableUnivariate
P valueMultivariate
P value
HR (95%CI)HR (95%CI)
Age, yr (≤ 65)0.831 (0.301-2.293)0.721--
Sex (female)0.493 (0.204-1.192)0.117--
BMI (≤ 25 kg/m2)0.703 (0.270-1.832)0.471--
ASA (I/II/III)1.440 (0.256-8.086)0.679--
Previous abdominal operation0.046 (0.000-250.286)0.482--
Primary site (L/M/LM)0.981 (0.707-1.360)0.908--
Tumor size (> 4 cm)2.607 (1.064-6.390)0.0361.180 (0.906-1.538)0.219
Neoadjuvant chemotherapy (Yes)1.369 (0.454-4,129)0.577--
Tumor grade (W/M/P/U)0.851 (0.578-1.253)0.415--
Lauren classification (I/D/M)0.949 (0.513-1.758)0.869--
pTNM stage (I/II/III)3.195 (1.518-6.724)0.0023.170 (1.461-6.878)0.004
Lymphovascular invasion (Yes)2.203 (0.906-5.358)0.081--
Neural infiltration (Yes)1.755 (0.715-4.304)0.219--
Surgical type (LaTSG/LaTG)2.977 (1.073-8.263)0.0362.876 (1.009-8.195)0.048
Operation time (> 210 min)1.130 (0.456-2.803)0.791--
Estimated blood loss (> 200 mL)1.261 (0.522-3.048)0.606--
Intraoperative blood transfusion (Yes)0.933 (0.273-3.192)0.912--
No. of retrieved lymph nodes (> 30)1.631 (0.590-4.511)0.346--
Proximal margin (> 3 cm)0.876 (0.362-2.120)0.770--
Distal margin (> 3 cm)0.500 (0.203-1.121)0.132--
Table 6 Univariate and multivariate analyses of disease free survival for included patients
VariableUnivariate
P valueMultivariate
P value
HR (95%CI)HR (95%CI)
Age, yr (≤ 65)0.505 (0.209-1.221)0.129--
Sex (female)0.795 (0.288-2.192)0.658--
BMI (≤ 25 kg/m2)0.675 (0.259-1.761)0.422-
ASA (I/II/III)1.864 (0.277-12.523)0.522--
Previous abdominal operation0.045 (0.000-188.621)0.467--
Primary Site (L/M/LM)0.993 (0.715-1.377)0.964--
Tumor size, (> 4 cm)2.535 (1.035-6.208)0.0421.740 (0.706- 4.294)0.229
Neoadjuvant chemotherapy (Yes)1.338 (0.442-4.051)0.606--
Tumor grade (W/M/P/U)0.852 (0.580-1.252)0.416--
Lauren classification (I/D/M)0.970 (0.523-1.798)0.923--
pTNM stage (I/II/III)3.317 (1.566-7.023)0.0023.353 (1.558-7.214)0.002
Lymphovascular invasion (Yes)2.209 (0.906-5.383)0.081--
Neural infiltration (Yes)1.729 (0.703-4.253)0.233--
Surgical type (LaTSG/LaTG)2.859 (1.027-7.958)0.0442.776 (0.981-7.854)0.054
Operation time (> 210 min)1.115 (0.450-2.761)0.814--
Estimated blood loss (> 200 mL)1.273 (0.526-3.080)0.592--
Intraoperative blood transfusion (Yes)0.938 (0.274-3.208)0.919--
No. of retrieved lymph nodes (> 30)1.643 (0.593-4.553)0.339--
Proximal margin (> 3 cm)0.904 (0.373-2.192)0.823--
Distal margin (> 3 cm)0.537 (0.219-1.319)0.175--