Basic Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Nov 21, 2020; 26(43): 6795-6809
Published online Nov 21, 2020. doi: 10.3748/wjg.v26.i43.6795
Table 1 Effect of oral (-)-fenchone and loperamide administration on castor oil-induced diarrhea in mice
Tratament (p.o.)Dose (mg/kg)EILiquid stools (%)Diarrheal inhibition (%)
Tween 80 5%23 (20-24)81
Loperamide57 (4-7)e887
(-)-Fenchone37, 516 (14-17)5228
(-)-Fenchone757 (6-7)a1951
(-)-Fenchone1504 (3-6)b481
(-)-Fenchone3003 (3-4)e488
Table 2 Effect of the evaluation of the minimum inhibitory concentration and minimum fungicide concentration (μg/mL) of (-)-fenchone against fungal strains
MIC (µg/mL)MFC (µg/mL)
Candida albicansATCC-766453232
Candida albicansLM-053232
Candida tropicalisATCC-138033232
Candida tropicalisLM-2032256
Candida kruzeiATCC-625864256
Candida kruseiLM-1364256
Table 3 Determination of the fractional inhibitory concentration index of the association between (-)-fenchone and amphotericin B on Candida albicans strains
StrainsFICA, (-)-fenchoneFICB, Amphotericin BFICIInteraction type
Candida albicans (ATCC-76645)112Indifferent
Candida albicans (LM-05)112Indifferent