Histopathological landscape of rare oesophageal neoplasms

doi:10.3748/wjg.v26.i27.3865

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2020; 26(27): 3865-3888
Published online Jul 21, 2020. doi: 10.3748/wjg.v26.i27.3865

Table 1 Main histological patterns and key immunophenotypic/molecular markers in oesophageal sarcomas

Tumour type	Histologic pattern	Immunohistochemical/molecular markers
GIST	Spindle cell	KIT
GIST	Spindle cell	DOG1
WDLS DDLS	Adipocytic	MDM2
	Spindle cell	CDK4
	Pleomorphic	p16
MLS	Myxoid	S100
MLS	Round cell	t (12; 16) (q13; p11): FUS-DDIT3
PLS	Pleomorphic	S100
MPNST	Spindle cell	S100
MPNST	Spindle cell	SOX10
PEComa	Epithelioid	Melan A
	Spindle cell	HMB45
		Smooth muscle actin
		Desmin
Solitary fibrous tumour	Spindle cell	STAT6
Solitary fibrous tumour	Spindle cell	CD34
Leiomyosarcoma	Spindle cell	Smooth muscle actin
	Myxoid	Smooth muscle actin
	Myxoid	Desmin
	Epithelioid	Desmin
Synovial sarcoma	Spindle cell	EMA
		Cytokeratins
		CD99
		TLE-1
		t (X; 18) (p 11.2; q 11.2) SYT-SSX
Kaposi sarcoma	Spindle cell	HHV-8
		CD31
		CD34
		ERG
Angiosarcoma	Epithelioid	CD31
	Spindle cell	CD34
	Spindle cell	ERG
Ewing sarcoma	Round cell	CD99
		FLI-1
		t (11; 22) (q24; q12): EWSR1-FLI1

GIST: Gastrointestinal stromal tumour; WDLS: Well-differentiated liposarcoma; DDLS: Dedifferentiated liposarcoma; MLS: Myxoid liposarcoma; PLS: Pleomorphic liposarcoma; MPNST: Malignant peripheral nerve sheath tumour.

Citation: Businello G, Dal Pozzo CA, Sbaraglia M, Mastracci L, Milione M, Saragoni L, Grillo F, Parente P, Remo A, Bellan E, Cappellesso R, Pennelli G, Michelotto M, Fassan M. Histopathological landscape of rare oesophageal neoplasms. World J Gastroenterol 2020; 26(27): 3865-3888
URL: https://www.wjgnet.com/1007-9327/full/v26/i27/3865.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i27.3865