Case Control Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Jun 14, 2020; 26(22): 3076-3086
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.3076
Table 1 Information of single nucleotide polymorphisms for calculating genetic risk score
ChromosomeSNPRegionRelated-genePrevious GWAS study
OP1RAORRAF
1rs109197911q32.1NR5A2EUA0.770.19
5rs27360985p15.33TERT, CLPTM1LEUT0.8NA1
5rs4016815p15.33CLPTM1LEUT1.190.49
5rs22552805p13.1DAB2CHG0.810.32
6rs23179006p25.3FOXQ1JAC1.2880.41
7rs69714997q32.3LINC-PINTEUC0.79NA1
7rs77795407q36.2DPP6JAA3.690.17
7rs1670207q36.3SHHEUA1.170.3
8rs15619278q24.21MIR1208, PVT1EUC0.87NA1
9rs20738289q34.2ABOEUA0.850.37
9rs5059229q34.2ABOEUC1.20.35
10rs1241362410q26.11PRLHRCHT1.230.42
12rs79286412p11.21BICD1JAA0.710.24
13rs958194313q12.2PDX1EUA1.46NA1
13rs488509313q22.1NACHC1.250.5
13rs954332513q22.1NAEUC1.260.37
16rs719045816q23.1BCAR1, CTRB1, CTRB2EUA1.46NA1
21rs37288321q21.3BACH1CHC0.790.39
21rs154737421q22.3TFF1CHG0.790.4
22rs1698682522q12.1ZNRF3EUT1.18NA1
22rs576870922q13.32FAM19A5CHG1.250.28
Table 2 Characteristics of study population
VariablesCase, n = 254Control, n = 1200P value
Sexn%n%
Male15664.4274862.230.831
Female9838.5845237.67
Age at diagnosis, mean ± SD63.3110.0148.8015.490.00012
GRS, mean ± SD1.963.841.090.94< 0.00013
GRS: < 112750.0072360.250.0021
GRS: 1-29135.8337431.17
GRS: > 23614.171038.58
< 10th P197.4812710.580.0071
10th-50th P8734.2549441.17
50th-90th P11143.7047139.25
90th P3714.571089.00
Table 3 Univariate/multivariate logistic regression results
Univariate logistic regressionOR (95%CI)P value
GRS1.23 (1.13-1.34)< 0.0001
Multivariate logistic regressionOR (95%CI)P value
GRS1.36 (1.06-1.74)0.015
Age at diagnosis/enrollment1.14 (1.12-1.17)< 0.0001
Sex0.84 (0.61-1.16)0.28
Subgroup analysis1OR (95%CI)P value
GRS: < 1 (Ref)2--
GRS: 1-21.39 (1.03-1.84)0.031
GRS: > 21.99 (1.30-3.04)0.002
< 10th P (Ref)3--
10th-50th P1.18 (0.69-2.01)0.548
50th-90th P1.57 (0.93-2.66)0.089
> 90th P2.29 (1.25-4.21)0.007