Basic Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Jun 14, 2020; 26(22): 3056-3075
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.3056
Table 1 Pharmacokinetic parameters of the eight components of Dachengqi decoction in serum (n = 6)
ParameterSOG1MG1MG2MG3
Emodin
AUC 0-t1605.0 ± 1029.5359.3 ± 187.1a362.5 ± 67.4427.5 ± 299.3
T 1/2z5.2 ± 1.418.9 ± 12.5a9.0 ± 3.222.6 ± 9.0
T max0.6 ± 0.33.5 ± 1.6a3.5 ± 1.60.3 ± 0dc
C max620.733 ± 477.034.1 ± 22.5a29.8 ± 8.8125.2 ± 90.9dc
Aloe-emodin
AUC 0-t19206.1 ± 7275.811860.0 ± 4393.2020181.9 ± 7660.237303.2 ± 13970.9d
T 1/2z7.0 ± 1.95.4 ± 2.16.4 ± 0.88.1 ± 5.4
T max1.6 ± 1.61.4 ± 0.73 ± 1.20.7 ± 0.3c
C max3797.0 ± 727.72203.9 ± 1156.12398.4 ± 708.98349.5 ± 3969.4dc
Rhein
AUC 0-t31571.7 ± 8961.813308.8 ± 8524.4a61966.5 ± 18335.3b38030.3 ± 22227.7dc
T 1/2z4.1 ± 1.56.5 ± 2.34.8 ± 0.820.8 ± 10.0dc
T max0.8 ± 0.26.5 ± 2.3a1.7 ± 0.7b1.6 ± 1.6d
C max11807.5 ± 2771.12204.3 ± 353.4a9245.7 ± 1284.0b11113.2 ± 5342.5d
Chrysophanol
AUC 0-t29977.3 ± 7570.015682.3 ± 5428.0a28337.7 ± 8880.5b26358.6 ± 4312.1d
T 1/2z5.7 ± 1.54.8 ± 1.0a4.7 ± 10.06.9 ± 4.5
T max1.4 ± 0.73.3 ± 3.2a1.5 ± 0.6b1.8 ± 1.7
C max7766.1 ± 2796.12018.9 ± 1227.5a4153.7 ± 2621.44318.1 ± 2458.9
Rheochrysidin
AUC 0-t867.505 ± 867.53665.5 ± 1693.3a3032.0 ± 1011.61510.264 ± 727.3d
T 1/2z6.1 ± 1.04.3 ± 1.24.3 ± 1.69.4 ± 1.5dc
T max1 ± 0.71.9 ± 1.52.2 ± 1.41.5 ± 0.6
C max197.5 ± 64.0728.8 ± 387.4a489.8 ± 176.2172.9 ± 110.7d
Naringin
AUC 0-t353.0 ± 261.06296.0 ± 1271.2a5449.1 ± 2183.02188.5 ± 752.5dc
T 1/2z6.4 ± 0.84.1 ± 0.7a5.4 ± 1.35.8 ± 5.8
T max0.8 ± 0.21.8 ± 1.72.3 ± 1.32.5 ± 1
C max125.6 ± 121.0806.2 ± 730.9a682.4 ± 380.4257.6 ± 26.4d
Naringenin
AUC 0-t3064.2 ± 829.96344.8 ± 1199.2a3051.6 ± 932.6b3926.0 ± 1014.2d
T 1/2z7.368 ± 1.54.5 ± 1.710.9 ± 3.4b7.8 ± 1.4
T max0.9 ± 0.72.3 ± 1.01.6 ± 1.60.6 ± 0.1d
C max634.2 ± 228.6805.3 ± 113.8488.9 ± 316.7581.1 ± 161.7
Magnolol
AUC 0-t143.8 ± 35.034.8 ± 8.0a69.4 ± 14.864.2 ± 10.8
T 1/2z9.0 ± 6.210.6 ± 1.413.9 ± 2.524.5 ± 9.1d
T max0.7 ± 0.30.8 ± 0.83.5 ± 1b0.5 ± 0.3c
C max30.6 ± 19.85.3 ± 1.7a5.5 ± 0.912.8 ± 3.1
Table 2 Concentrations of the ten major components of Dachengqi decoction in tissue samples (n = 6)
ParameterSOG1MG1MG2MG3
Heart
Emodin3.21 ± 0.131.25 ± 0.09ad2.24 ± 0.14c2.45 ± 0.21
Aloe-emodin56.72 ± 5.6721.96 ±7.21ad28.45 ± 8.4731.53 ± 1.34
Rhein0000
Chrysophanol15.57 ± 4.636.43 ± 1.2a5.65 ± 2.47.59 ± 1.98
Rheochrysidin1.93 ± 0.89002.41 ± 3.67
Naringin40.36 ± 1.380.85 ± 0.02ad9.62 ± 0.37c10.49 ± 0.21
Naringenin420.68 ± 67.81160.09 ± 12.61a924.79 ± 34.67c270.25 ± 48.51
Hesperidin12.22 ± 0.945.05 ± 1.2a10.33 ± 4.3 c5.24 ± 1.98
Magnolol0.21 ± 0.040.18 ± 0.020.02 ± 0.01 c0.21 ± 0.10
Honokiol0.59 ± 0.070.24 ± 0.04ad0.9 0 ± 0.07 c0.73 ± 0.09
Liver
Emodin14.24 ± 6.217.27 ± 2.37a3.97 ± 1.67 c8.36 ± 4.23
Aloe-emodin506.09 ± 32.78438.4 ± 123.47122.87 ± 79.23 c383.40 ± 101.31
Rhein45.58 ± 63.23000
Chrysophanol132.65 ± 7.4340.38 ± 20.81ad17.10 ± 3.24 c18.47 ± 0.8
Rheochrysidin20.27 ± 0.981.42 ± 0.14ad3.39 ± 0.29 c0.18 ± 0.23
Naringin148.20 ± 8.9413.19 ± 10.23a27.07 ± 9.8123.49 ± 8.67
Naringenin1707.40 ± 99.461459.04 ± 98.67ad692.88 ± 102.43c1855.76 ± 79.23
Hesperidin60.03 ± 18.876.53 ± 1.23ad2.27 ± 0.94c13.65 ± 0.23
Magnolol2.88 ± 0.413.34 ± 1.641.62 ± 0.72 c2.42 ± 0.23
Honokiol3.00 ± 0.782.02 ± 0.781.64 ± 0.243.03 ± 0.31
Lung
Emodin3.87 ± 1.432.08 ± 0.982.99 ± 0.433.1 ± 1.02
Aloe-emodin66.98 ± 33.6256.88 ± 20.45d34.94 ± 13.67 c88.12 ± 23.21
Rhein143.74 ± 73.64164.27 ± 64.8172.59 ± 42.31 c171.52 ± 57.84
Chrysophanol19.05 ± 6.3913.51 ± 9.4315.1 ± 3.5716.42 ± 4.81
Rheochrysidin1.06 ± 0.170.18 ± 0.23a0.42 ± 0.02c0.23 ± 0.01
Naringin12.55 ± 1.676.00 ± 3.2ad8.37 ± 2.37c24.46 ± 4.17
Naringenin422.09 ± 203.92601.12 ± 176.64567.53 ± 123.67427.36 ± 204.81
Hesperidin58.67 ± 15.8122.74 ± 10.13ad33.74 ± 10.32c77.35 ± 34.61
Magnolol0.34 ± 0.190.35 ± 0.230.35 ± 0.040.46 ± 0.17
Honokiol1.43 ± 0.191.42 ± 0.16a0.95 ± 0.02 c0.82 ± 0.04
Kidney
Emodin21.15 ± 10.2827.75 ± 14.2111.98 ± 5.67 c26.31 ± 13.42
Aloe-emodin1328.18 ± 159.73279.04 ± 100.04ad133.62 ± 92.43c720.74 ± 143.67
Rhein154.59 ± 12.342.49 ± 0.98ad37.72 ± 1.34c101.55 ± 2.78
Chrysophanol108.89 ± 7.64101.18 ± 7.84ad46.84 ± 6.23c124.76 ± 4.32
Rheochrysidin16.25 ± 2.7915.23 ± 3.546.13 ± 0.98c13.57 ± 1.43
Naringin208.08 ± 8.9418.44 ± 3.64ad0.94 ± 0.17c59.9 ± 7.63
Naringenin2144.99 ± 147.812506.95 ± 100.07ad2360.21 ± 143.64c1939.2 ± 127.68
Hesperidin48.87 ± 4.819.13 ± 1.67a8.67 ± 1.329.90 ± 0.89
Magnolol0.81 ± 0.20.52 ± 0.12ad0.30 ± 0.03 c1.14 ± 0.14
Honokiol2.76 ± 0.311.56 ± 0.44ad1.35 ± 0.23c2.63 ± 0.67
Intestine
Emodin94.43 ± 37.2319.73 ± 6.72ad88.3 ± 24.23122.66 ± 72.61
Aloe-emodin4515.56 ± 342.671447.33 ± 109.73ad975.33 ± 152.62c2202.32 ± 143.76
Rhein214.49 ± 56.72830.8 ± 48.63ad130.67 ± 65.67209.09 ± 100.3
Chrysophanol714.88 ± 300.68290.97 ± 110.37ad410.67 ± 203.3c736.46 ± 45.67
Rheochrysidin161.78 ± 80.9337.9 ± 2.34ad27.59 ± 17.61c191.14 ± 59.67
Naringin2771.61 ± 67.81604.19 ± 134.6ad678.67 ± 57.63c1442.36 ± 100.75
Naringenin1804.34 ± 307.161365.3 ± 153.62ad1077.59 ± 174.63 c3695.62 ± 483.54
Hesperidin1156.54 ± 154.63241.58 ± 72.61ad265.59 ± 100.32 c581.04 ± 201.63
Magnolol17.13 ± 7.3418.78 ± 6.43d18.15 ± 7.81c35.5 ± 5.67
Honokiol18.7 ± 2.7124.27 ± 2.43ad17.14 ± 3.1c45.48 ± 4.58