Role of γδT cells in liver diseases and its relationship with intestinal microbiota

Table 1 The roles of γδT cells in liver diseases

Liver diseases	Mechanisms of γδT cells	Functions
Viral hepatitis	Production of IFN-γ, TNF-α; Expression of CD107a; Downregulation of IL-17, IL-22	Amelioration
	Exhaustion of CD8+T cells; Production of IL-17 and TNF-α	Aggravation
Liver bacterial, fungal and parasitic infections	Production of IL-9, IL-17, TNF-α	Protection
Autoimmune liver diseases	Production of IL-10 and granzymes; Expression of CD39, CD73, NKG2D; Downregulation of NKT cells	Amelioration
	Expression of IL-17; Apoptosis of Tregs	Aggravation
Nonalcoholic fatty liver disease	Expression of IL-17	Aggravation
Liver fibrosis and cirrhosis	Expression of IL-17	Aggravation
	Apoptosis of HSC	Amelioration
Liver tumors	Expression of Ia and LFA-1, CD56 and CD161; Production of IFN-γ, perforin	Anti-tumor

IFN-γ: Interferon-γ; TNF-α: Tumor necrosis factor-α; IL-17: Interleukin-17; NKT: Natural killer T; HSC: Hepatic stellate cells.