Copyright ©The Author(s) 2020.
World J Gastroenterol. May 28, 2020; 26(20): 2559-2569
Published online May 28, 2020. doi: 10.3748/wjg.v26.i20.2559
Table 1 The roles of γδT cells in liver diseases
Liver diseasesMechanisms of γδT cellsFunctions
Viral hepatitisProduction of IFN-γ, TNF-α; Expression of CD107a; Downregulation of IL-17, IL-22Amelioration
Exhaustion of CD8+T cells; Production of IL-17 and TNF-αAggravation
Liver bacterial, fungal and parasitic infectionsProduction of IL-9, IL-17, TNF-αProtection
Autoimmune liver diseasesProduction of IL-10 and granzymes; Expression of CD39, CD73, NKG2D; Downregulation of NKT cellsAmelioration
Expression of IL-17; Apoptosis of TregsAggravation
Nonalcoholic fatty liver diseaseExpression of IL-17Aggravation
Liver fibrosis and cirrhosisExpression of IL-17Aggravation
Apoptosis of HSCAmelioration
Liver tumorsExpression of Ia and LFA-1, CD56 and CD161; Production of IFN-γ, perforinAnti-tumor