MiR-301a transcriptionally activated by HIF-2α promotes hypoxia-induced epithelial-mesenchymal transition by targeting TP63 in pancreatic cancer

Table 1 Abdominal and lymph node metastases in the miR-301a overexpression group are significantly increased

	MiR-301a	NC	P value
Mouse weight (g)	20.90 ± 2.42	20.07 ± 1.58	0.42
Tumor weight (g)	1.96 ± 0.93	2.37 ± 0.87	0.36
Incidence of ascites	6/10	3/9	0.483
Abdominal metastasis	9/10	2/9	0.012
Liver metastasis	2/10	2/9	1.000
Pulmonary metastasis	2/10	1/9	1.000
Lymph node metastases	5/10	0/10	0.039

Table 2 Clinicopathological correlations of miR-301a expression in pancreatic cancer tissue microarray

		MiR-301a expression
Parameters	n	Negative	Positive	P value
Tissueb				0.005
Nontumor	80	42	38
Tumor	100	32	68		↑
Age, yr				0.064
≤ 60	49	20	29
> 60	51	12	39
Sex				0.338
Male	63	18	45
Female	37	14	23
Tumor size (cm)				0.794
≤ 5	60	19	41
> 5	38	13	25
Missing data	2
Tumor location				0.378
Head	62	21	41
Body or tail	32	8	24
Missing data	6
T stage				0.363
T1	4	2	2
T2	74	26	48
T3	20	4	16
Missing data	2
N stagec				0.001
N0	54	28	26
N1	39	5	34		↑
Missing data	7
Tumor gradea				0.016
I-II	68	27	41
III	32	5	27		↑
AJCC stageb				0.007
0-IIa	51	22	29
IIb- IV	41	7	34		↑
Missing data	8

χ² test:

^aP < 0.05,

^bP < 0.01,

^cP < 0.001. AJCC: American Joint Committee on Cancer.