Copyright ©The Author(s) 2020.
World J Gastroenterol. May 14, 2020; 26(18): 2155-2165
Published online May 14, 2020. doi: 10.3748/wjg.v26.i18.2155
Table 1 Natural products that target macrophage for nonalcoholic steatohepatitis therapy
Macrophage activationSparstolonin BHFD-fed mice↓CD68, MCP-1[23]
CurcuminoidsLPS-treated BALB/C mice↓Phagocytic activity of KCs[24]
S. miltiorrhiza extractCCl4-induced liver injury rats↓p38, NF-κB signaling[25]
Extract of Graptopetalum paraguayenseLiver fibrosis rats, primary HSCs and KCs↓KC activation, nitric oxide, TNF-α, IL-6[26]
Alisma orientale extractPA-stimulated HepG2 cells, NAFLD mice↓ER stress, lipogenic gene expression[30,31]
MyriocinCo-culture SPT with myriocin↓SPT activation[32]
Gallic acidHFD-induced NAFLD mice↓TMA, DMA[37]
BerberineNAFLD miceClostridium cluster XIVa and IV;[38]
Dendrobium extractdb/db mice↑The bacteroidetes to firmicutes ratio, Prevotella, Akkermansia; ↓S24-7, Rikenella, Escherichia coli.[39]
DihydromyricetinAdult NAFLD patients↓Resistin, IR[40]
Korean Red GinsengNAFLD patients↑Adiponectin, ↓TNF-α[41]
Total alkaloids of Rubus alceaefolius PoirHFD-fed NAFLD rats↑Adiponectin; ↓Leptin, resistin[42]
Opuntia ficus indicaObese Zucker (fa/fa) rats↑Adiponectin; ↓leptin, IR[43]
UmbelliferoneHFD- and STZ-induced type 2 diabetic rats↑Adiponectin; ↓leptin, IR[44]
PiperineHFD-induced obese rats↑Adiponectin; ↓leptin, IR[45]
Macrophage recruitmentFlavonoidsMice↓CCR2, CXCL10, CCR10[48]
BroccoliDSS-induced colitis mice↓CCR2[49]
BerberineHFD-fed rats↓CCL2[50]
Rudgea viburnoides (Cham.) Benth. (Rubiaceae) leavesHC-diet fed BALB/c mice↓CCL2[51]
Total aralosides of Aralia elata (Miq) seemHFD-induced NASH mice, ApoE-/- mice↓CCL2, JNK signaling pathway[52]
Macrophage polarizationCelastrolRAW264.7 cells and diet-induced obese mice↓TNF-α, IL-6, IL-1β, iNOS, MAPK activation, NF-κB nuclear translocation; ↑Nrf2 and HO-1[64]
Smiglaside ALPS-stimulated RAW264.7 cells, mouse peritoneal macrophages↑AMPK-PPARγ, M2-type macrophages; ↓M1-type macrophages[65]
AsperlinLPS-stimulated RAW264.7 cells↓TNF-α, IL-1β, iNOS; ↑IL-4, IL-10[66]
The pentacyclic triterpene lupeolDSS-induced colitis mice↓TNF-α, IL-6, IL-1β, IL-12, p38, MAPK, CD86, IRF5; ↑IL-10, CD206[67]
BaicalinBMDMs, PMs, colitis mice↓TNF-α, IL-6, IL-23, IRF5; ↑IL-10, Arg-1, IRF4[68,69]
Tanshinone IIAHFD fed ApoE-/- mice↑M2-type macrophage, ↓miR-375[70]
Tabebuia avellanedae Lorentz ex Griseb extractMesenteric lymph nodes of DSS-induced colitis mice↑M2-type macrophage[71]
EmodinPrimary mouse macrophages↓NF-κB/IRF5/STAT1 and IRF4/STAT6 signaling, H3K27 acetylation; ↑H3K27 trimethylation[10]
Trichosanthes kirilowii lectinSTZ-induced diabetic DN rats↓Notch signaling[73]
OridoninLPS-stimulated RAW264.7 cells↓Notch signaling[74]
Macrophage metabolismAmpelopsis brevipedunculata (Vitaceae) berriesFerrous iron-stimulated rat hepatocyte↓Pyruvate, superoxide dismutase, dimethyl sulfoxide[94]
Aim Scutellariae Radix and Coptidis RhizomaHFD-induced diabetic rats↑Pyruvate kinase activities[95]
Hyacinth beanHFD-fed mice↓Pyruvate-derived amino acids metabolism[96]
Mycetia cauliflora Reinw.LPS-activated RAW264.7 cells↓PDK1, NF-κB signaling pathway[98]
Dipterocarpus tuberculatus Roxb.LPS-activated RAW264.7 cells↓PDK1, NF-κB signaling pathway[99]